863642-44-8 Usage
Description
(2R,3R,4R)-3-(benzyloxy)-2-(benzyloxymethyl)-4-fluoro-5-methoxy-tetrahydrofuran, also known as benzyl ether, is a tetrahydrofuran compound with a benzyloxy and benzyloxymethyl group attached at the 3rd and 2nd carbon positions, respectively. It also contains a fluorine atom at the 4th carbon and a methoxy group at the 5th carbon. Tetrahydrofurans are commonly used as solvents and reagents in organic chemistry. The presence of benzyl groups in this compound makes it useful as a protective group in organic synthesis, as the benzyl groups can be easily removed under mild conditions, allowing for the selective modification of other functional groups in the molecule. Additionally, the fluoro and methoxy groups can affect the compound's reactivity and biological activity.
Uses
Used in Organic Synthesis:
(2R,3R,4R)-3-(benzyloxy)-2-(benzyloxymethyl)-4-fluoro-5-methoxy-tetrahydrofuran is used as a protective group for other functional groups in organic synthesis. The benzyl groups can be easily removed under mild conditions, allowing for selective modification of other functional groups in the molecule.
Used in Solvents and Reagents:
(2R,3R,4R)-3-(benzyloxy)-2-(benzyloxymethyl)-4-fluoro-5-methoxy-tetrahydrofuran is used as a solvent and reagent in organic chemistry due to its tetrahydrofuran structure.
Used in Pharmaceutical Industry:
(2R,3R,4R)-3-(benzyloxy)-2-(benzyloxymethyl)-4-fluoro-5-methoxy-tetrahydrofuran is used as a building block for the synthesis of pharmaceutical compounds. The fluoro and methoxy groups can affect the compound's reactivity and biological activity, making it a valuable component in the development of new drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 863642-44-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,3,6,4 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 863642-44:
(8*8)+(7*6)+(6*3)+(5*6)+(4*4)+(3*2)+(2*4)+(1*4)=188
188 % 10 = 8
So 863642-44-8 is a valid CAS Registry Number.
863642-44-8Relevant articles and documents
CYCLIC DINUCLEOTIDE COMPOUND AND USES THEREOF
-
, (2021/11/05)
Provided are a compound of formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, uses of said compound acting as a STING agonist.
Stereoselective C-glycosylation reactions of ribose derivatives: Electronic effects of five-membered ring oxocarbenium ions
Larsen, Catharine H.,Ridgway, Brian H.,Shaw, Jared T.,Smith, Deborah M.,Woerpel
, p. 10879 - 10884 (2007/10/03)
The factors controlling the highly α-selective C-glycosylation of ribose derivatives were determined by examining the Stereoselective reactions of 18 ribose analogues differing in substitution at C-2, C-3, and C-4. The lowest energy conformers of the intermediate oxocarbenium ions display the C-3 alkoxy group in a pseudoaxial orientation to maximize electrostatic effects. To a lesser extent, the C-2 substituent prefers a pseudoequatorial position, and the alkyl group at C-4 has little influence on conformational preferences. In all cases, the product was formed by stereoelectronically preferred inside attack on the lowest energy conformer.
