86394-97-0

Basic information

• Product Name: 2-Propenoic acid, 3-phenyl-, 2-(aminosulfonyl)-6-benzothiazolyl ester
• CAS NO: 86394-97-0
• Molecular Formula: C16H12N2O4S2
• Molecular Weight: 360.414
• Mol File: 86394-97-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-phenyl-, 2-(aminosulfonyl)-6-benzothiazolyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-phenyl-, 2-(aminosulfonyl)-6-benzothiazolyl ester(86394-97-0)
• EPA Substance Registry System: 2-Propenoic acid, 3-phenyl-, 2-(aminosulfonyl)-6-benzothiazolyl ester(86394-97-0)

Safety Data

• Hazardous Substances Data: 86394-97-0(Hazardous Substances Data)

Upstream product

• 5304-15-4 6-ethoxy-2-benzothiazolesulfenamide 
• 120-53-6 6-ethoxy-2-mercaptobenzothiazole 
• 452-35-7 6-ethoxybenzothiazole-2-sulfonamide 
• 102-92-1 cinnamoyl chloride 
• 29927-14-8 6-hydroxy-2-benzothiazolesulfonamide 

Relevant articles and documents

Topically Active Carbonic Anhydrase Inhibitors. 1. O-Acyl Derivatives of 6-Hydroxybenzothiazole-2-sulfonamide

A series of O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide (4, L-643,799) was prepared and the potential utility of each series member as a topically active inhibitor of ocular carbonic anhydrase was determined.In vitro studies showed these esters to be substrates for ocular esterases which liberate 4 during corneal translocation.The most interesting series member, 2-sulfamoyl-6-benzothiazolyl 2,2-dimethylpropionate (22, L-645,151), acting as a prodrug form of 4, was found to enhance delivery through the isolated albino rabbit cornea by 40-fold when compared to the parent phenol 4.Studies in rabbits revealed that 22 is a potent topically active ocular hypotensive carbonic anhydrase inhibitor.