864672-63-9

Basic information

• Product Name: tert-butyl (3-(4-formyl-2-methoxy-5-nitrophenoxy)-propyl)carbamate
• Synonyms: tert-butyl (3-(4-formyl-2-methoxy-5-nitrophenoxy)-propyl)carbamate
• CAS NO: 864672-63-9
• Molecular Weight: 354.36
• Mol File: 864672-63-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl (3-(4-formyl-2-methoxy-5-nitrophenoxy)-propyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (3-(4-formyl-2-methoxy-5-nitrophenoxy)-propyl)carbamate(864672-63-9)
• EPA Substance Registry System: tert-butyl (3-(4-formyl-2-methoxy-5-nitrophenoxy)-propyl)carbamate(864672-63-9)

Safety Data

• Hazardous Substances Data: 864672-63-9(Hazardous Substances Data)

Upstream product

• 58885-58-8 N-tert-butoxycarbonyl-3-aminopropanol 
• 2454-72-0 6-nitrovanillin 
• 121-33-5 vanillin 
• 83948-53-2 3-bromopropylamine tert-butylcarbamate 
• 2426-84-8 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 

Downstream Products

• 864672-64-0 tert-butyl (S)-(3-(4-(2-(hydroxymethyl)pyrrolidine-carbonyl)-2-methoxy-5-nitrophenoxy)propyl)carbamate 
• 1025740-51-5 tert-butyl (S)-(3-(5-amino-4-(2-(hydroxymethyl)-pyrrolidine-1-carbonyl)-2-methoxyphenoxy)propyl)carbamate 
• 864672-65-1 tert-butyl (S)-(3-(5-(((allyloxy)carbonyl)amino)-4-(2-(hydroxymethyl)pyrrolidine-1-carbonyl)-2-methoxyphenoxy)propyl)carbamate 
• 757189-87-0 4-(3-((tert-butoxycarbonyl)amino)propoxy)-5-methoxy-2-nitrobenzoic acid 

Relevant articles and documents

An asymmetric C8/C8′-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs

A novel sequence-selective extended PBD dimer 4 has been synthesized that binds with high affinity to an interstrand cross-linking site spanning 11 DNA base pairs. Despite its molecular weight (984.07) and length, the molecule has significant DNA interstrand cross-linking potency (～100-fold greater than the clinically used agent melphalan) and sub-micromolar cytotoxicity in a number of tumour cell lines, suggesting that it readily penetrates cellular and nuclear membranes to reach its DNA target.

C/8/C8' LINKED 5-OXO-1,2,3,11A-TETRAHYDRO-5H-PYRROLO`2,1-C!`1,4!BENZODIAZEPINE DIMERS WITH 1H-PYRROLE-DICARBOXYLIC ACID AMIDE LINKERS AND OLIGOMERIC ANALOGS THEROF AS WELL AS RELATED COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISEASES

Compounds of formula (I): PBD-A-Y-X- (Het)na-L- (Het)nb-L- (Het)nc-T- (Het')nd-L- (Het')ne-L- (Het')nf-X' -Y' -A' -PBD' and salts, solvates and chemically protected forms thereof, are disclosed wherein the PBD units have the formulae (PBD) (PBD') with the bonds at the 8 position on each molecule bond to the A and A' groups respectively ; A is selected from O, S, NH or a single bond , and each Het and Het' is respectively an amino-heteroarylene-carbonyl group ; X and X' are both either NH or C (=O) -Q-C (=O) - wherein Q is a divalent group such that HY = R ; in a second aspectm the invention comprises compounds of the general formula (II) : PBD-A-Y-X-(Het)ng-[L-(Het)nh] nj-X' -Y' -A' -PBD'. Wherein : PBD and PBD' are as defined above, X and X' are either NH and C(=O) respectively or C(O) and NH respectively ; the other substituents are defined in the claims. Further aspects of the present invention relate to their use in the manufacture of a medicament for the treatment of a proliferative disease.