86552-32-1

Basic information

• Product Name: (4-PHENYLBUTYL)PHOSPHINIC ACID
• Synonyms: (4-PHENYLBUTYL)PHOSPHINIC ACID
• CAS NO: 86552-32-1
• Molecular Formula: C₁₀H₁₅O₂P
• Molecular Weight: 198.2
• Mol File: 86552-32-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 361.2±35.0 °C(Predicted)
• Appearance: /
• PKA: 3.41±0.10(Predicted)
• CAS DataBase Reference: (4-PHENYLBUTYL)PHOSPHINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-PHENYLBUTYL)PHOSPHINIC ACID(86552-32-1)
• EPA Substance Registry System: (4-PHENYLBUTYL)PHOSPHINIC ACID(86552-32-1)

Safety Data

• Hazardous Substances Data: 86552-32-1(Hazardous Substances Data)

Usage

General Description

(4-Phenylbutyl)phosphinic acid is a chemical compound that belongs to the phosphinic acid family, which contains a phosphorus atom bonded to a carbon atom via a double bond. (4-PHENYLBUTYL)PHOSPHINIC ACID has a phenyl group attached to a four-carbon chain, and the phosphinic acid group is bonded to the second carbon atom. It is mainly used as a ligand in metal coordination chemistry and as a building block for the synthesis of various organic compounds. This chemical has applications in catalysis, pharmaceuticals, and material sciences. It has also been studied for potential use in the treatment of various medical conditions due to its biological and therapeutic properties.

Upstream product

• 768-56-9 4-Phenylbut-1-ene 
• 10039-56-2 sodium hypophosphite 
• 60-29-7 diethyl ether 
• 34241-39-9 azobisisobutyronitrile 
• 86552-35-4 (4-phenylbutyl)-phosphinic acid,ethyl ester 
• 2270-20-4 5-Phenylpentanoic acid 

Downstream Products

• 95986-01-9 ((E)-1-Hydroxy-but-2-enyl)-(4-phenyl-butyl)-phosphinic acid 
• 95986-02-0 (1-Hydroxy-1,3-dimethyl-but-2-enyl)-(4-phenyl-butyl)-phosphinic acid 
• 95986-04-2 4-[Hydroxy-(4-phenylbutyl)phosphinyl]-4,4-dimethyl-2-butanone 
• 95986-15-5 (3-Oxo-cyclopentyl)-(4-phenyl-butyl)-phosphinic acid 
• 86552-35-4 (4-phenylbutyl)-phosphinic acid,ethyl ester 
• 111496-36-7 (4-phenylbutyl)phosphonous acid 1-adamantylamine salt 
• 107492-14-8 (S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoic acid methyl ester 
• 117085-70-8 (S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-2,3-dihydro-1H-indole-2-carboxylic acid benzhydryl ester 

Relevant articles and documents

Environmentally benign synthesis of H-phosphinic acids using a water-tolerant, recyclable polymer-supported catalyst

(Chemical Equation Presented) A reusable polymer-supported hydrophosphinylation catalyst is described for the preparation of H-phosphinic acids. The polystyrene-based ligand is prepared in one step from commercially available compounds. The polymeric catalyst generally gives good yields for a variety of substrates and is water- and air-tolerant, although the scope of alkenes and alkynes which can be employed is somewhat narrower than with our original xantphos/Pd2dba3 catalyst.

Method for preparation of alkyl phosphonyl compound from peroxide

The invention discloses a method for preparation of an alkyl phosphonyl compound from peroxide. The invention adopts an acyl peroxide as the starting material, and the raw material is easily availableand has a great variety. The product obtained by the method provided by the invention has a great variety and wide uses. Some of the products can be reduced simply into important phosphorus ligands and key pharmaceutical intermediates. In addition, the method avoids the use of high toxicity phosphine reagent, has the characteristics of mild reaction conditions, simple operation, high target product yield, low pollution, simple reaction operation and post-treatment process, and is suitable for industrial production.

Hydrophosphinylation of unactivated terminal alkenes catalyzed by nickel chloride

The room-temperature hydrophosphinylation of unactivated monosubstituted alkenes using phosphinates (ROP(O)H2) and catalytic NiCl2 in the presence of dppe is described. The method is competitive with prior palladium-catalyzed reactio