866030-36-6

Basic information

• Product Name: Aliskiren inter-6
• Synonyms: [(1S,3S)-3-[[4-Methoxy-3-(3-methoxypropoxy)phenyl]methyl]-1-[(methoxymethylamino)carbonyl]-4-methylpentyl]carbamic acid 1,1-dimethylethyl ester;Aliskiren inter-6
• CAS NO: 866030-36-6
• Molecular Formula: C₂₆H₄₄N₂O₇
• Molecular Weight: 496.64
• Mol File: 866030-36-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.068
• Refractive Index: 1.495
• CAS DataBase Reference: Aliskiren inter-6(CAS DataBase Reference)
• NIST Chemistry Reference: Aliskiren inter-6(866030-36-6)
• EPA Substance Registry System: Aliskiren inter-6(866030-36-6)

Safety Data

• Hazardous Substances Data: 866030-36-6(Hazardous Substances Data)

Usage

General Description

Aliskiren inter-6 is a chemical compound used in the development of aliskiren, a medication used to treat high blood pressure. Aliskiren works by binding to and inhibiting the enzyme renin, which plays a key role in regulating blood pressure. By inhibiting renin, aliskiren helps to relax and widen blood vessels, reducing the resistance that the heart must overcome to pump blood, thus lowering blood pressure. Aliskiren inter-6 is an important intermediate in the synthesis of aliskiren, playing a crucial role in the production of this medication. It is a key component in the manufacturing process of aliskiren, and its quality and purity are essential for the effectiveness and safety of the final medication.

InChI:InChI=1/C26H44N2O7/c1-18(2)20(15-19-11-12-22(32-8)23(16-19)34-14-10-13-31-7)17-21(24(29)28(6)33-9)27-25(30)35-26(3,4)5/h11-12,16,18,20-21H,10,13-15,17H2,1-9H3,(H,27,30)/t20-,21-/m0/s1

Upstream product

• 866030-33-3 (2R,5S)-3,6-diethoxy-2-isopropyl-5-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-2,5-dihydropyrazine 
• 621-59-0 isovanillin 
• 145589-03-3 (R)-4-benzyl-3-(3-methylbutyryl)oxazolidin-2-one 
• 172900-75-3 4-methoxy-3-(3-methoxypropoxy)benzaldehyde 
• 172900-70-8 (R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol 
• 172900-71-9 (R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid 
• 172900-73-1 4-(bromomethyl)-1-methoxy-2-(3-methoxypropoxy)-benzene 
• 172900-69-5 (R)-4-(2-(bromomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene 
• 172900-99-1 (2S,4S)-2-Amino-4-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-5-methyl-hexanoic acid ethyl ester 
• 172900-76-4 ethyl (2S,4S)-2-{[(tert-butoxy)carbonyl]amino}-4-[4-methoxy-3-(3-methoxypropoxy)benzyl]-5-methylhexanoate 
• 172900-72-0 (4R)-3-{(2R)-2-{[4-methoxy-3-(methoxypropoxy)phenyl]methyl-3-methyl}-1-oxobutyl}-4-(phenylmethyl)oxazolidin-2-one 

Downstream Products

• 866030-37-7 Benzyl-[(1S,3S)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-1-(methoxy-methyl-carbamoyl)-4-methyl-pentyl]-carbamic acid tert-butyl ester 
• 866030-38-8 Benzyl-{(1S,3S)-1-formyl-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid tert-butyl ester 
• 866030-40-2 ((1S,2R,4S)-2-Hydroxy-4-hydroxymethyl-1-{(S)-2-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-3-methyl-butyl}-5-methyl-hexyl)-carbamic acid tert-butyl ester 
• 866030-39-9 Benzyl-((1S,2R,4S)-4-benzyloxymethyl-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-3-methyl-butyl}-5-methyl-hexyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Practical synthesis of an orally active renin inhibitor aliskiren

A convergent synthesis of aliskiren was accomplished via the use of Segment AB as the key intermediate, which was prepared via the coupling of the Grignard reagent derived from Segment B with Segment A, followed by subsequent oxidative lactonization.