86674-49-9 Usage
Description
1-nitropyrene-3-ol is a nitroarene compound that has been identified as a potential contributor to genotoxicity associated with air pollution. Its chemical structure and properties make it a compound of interest for further research and potential applications in various fields.
Uses
Used in Environmental Monitoring and Research:
1-nitropyrene-3-ol is used as a biomarker for monitoring air pollution levels and assessing the genotoxic potential of particulate matter in the atmosphere. Its presence in air samples can provide valuable information on the sources and distribution of genotoxic pollutants, aiding in the development of strategies to reduce exposure and mitigate their harmful effects on human health and the environment.
Used in Toxicology Studies:
1-nitropyrene-3-ol serves as a model compound in toxicology research, helping scientists to understand the mechanisms of genotoxicity and carcinogenicity associated with nitroarene exposure. By studying its interactions with biological systems, researchers can gain insights into the molecular pathways and processes that contribute to the toxic effects of air pollutants, ultimately leading to the identification of potential targets for intervention and prevention.
Used in Analytical Chemistry:
1-nitropyrene-3-ol can be employed as a reference material in the development and validation of analytical methods for the detection and quantification of genotoxic compounds in environmental and biological samples. Its unique chemical properties make it a suitable candidate for the calibration of instruments and the optimization of extraction and detection techniques, ensuring accurate and reliable measurements in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 86674-49-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,6,7 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 86674-49:
(7*8)+(6*6)+(5*6)+(4*7)+(3*4)+(2*4)+(1*9)=179
179 % 10 = 9
So 86674-49-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H9NO3/c18-14-8-13(17(19)20)11-6-4-9-2-1-3-10-5-7-12(14)16(11)15(9)10/h1-8,18H
86674-49-9Relevant articles and documents
Photodegradation mechanisms of 1-nitropyrene, an environmental pollutant: The effect of organic solvents, water, oxygen, phenols, and polycyclic aromatics on the destruction and product yields
Garcia-Berrios, Zulma I.,Arce, Rafael
experimental part, p. 3662 - 3664 (2012/06/30)
This work describes studies of the photodegradation mechanism of 1-nitropyrene (1-NO2Py) in a chemical model system consisting of an organic solvent and known constituents of an aerosol particle. Photoproducts such as 1-hydroxypyrene (1-OHPy),
Chemical Oxidation of Nitrated Polycyclic Aromatic Hydrocarbons: Hydroxylation with Superoxide Anion Radical
Fukuhara, Kiyoshi,Miyata, Naoki
, p. 27 - 33 (2007/10/03)
Nitrated polycyclic aromatic hydrocarbon (nitroPAH) is a potent mutagen which is reductively and/or oxidatively metabolized. Biological oxidation of nitroPAH, such as hydroxylation and epoxidation, is known, but chemical oxidation has been reported in only a few papers. NitroPAH is barely oxidized by various chemical oxidants because of the electron deficient property of the aromatic ring with the nitro substituent. Nucleophilic reactivity of superoxide anion radical is known, and thus the oxidation of nitroPAH with the chemically generated superoxide anion radical was carried out in this study. When 1-nitropyrene was reacted with KO2/18-crown-6 in dimethylformamide, 5-, 6-, 8-, and 9-hydroxy-1-nitropyrenes and 1-hydroxypyrene were obtained in preparative yields. Three isomeric dinitropyrenes, 3-nitrofluoranthene, 6-nitrobenzopyrene, and 6-nitrochrysene, were oxidized to hydroxy derivatives, some of which correspond to the oxidative metabolite of nitroPAH. The oxidation of dinitropyrenes with trifluoroperacetic acid gave K-region oxidized products.