867187-56-2Relevant articles and documents
Indenone derivatives: A novel template for peroxisome proliferator- activated receptor γ (PPARγ) agonists
Ahn, Jin Hee,Shin, Mi Sik,Jung, Sun Ho,Kang, Seung Kyu,Kim, Kwang Rok,Rhee, Sang Dal,Jung, Won Hoon,Yang, Sung Don,Kim, Seung Jun,Woo, Joo Rang,Lee, Jeong Hyung,Cheon, Hyae Gyeong,Kim, Sung Soo
, p. 4781 - 4784 (2006)
Agonists of peroxisome proliferator-activated receptor γ(PPAR γ) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR γ agonist. Moreover, compound 14c has displayed the most active agonistic activi
INDENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
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Page/Page column 36-37, (2010/02/14)
The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.
