867187-59-5Relevant articles and documents
Mechanochemical Solvent-Free Synthesis of Indenones from Aromatic Carboxylic Acids and Alkynes
Li, Liang,Wang, Guan-Wu
, p. 14102 - 14112 (2021/09/07)
The mechanochemical solvent-free synthesis of indenones from aromatic carboxylic acids and alkynes was achieved through triflic anhydride (Tf2O)-induced cyclization reaction. A variety of indenones including a bioactive PPARγagonist were obtained in up to 90% yield at room temperature. The present protocol has the advantages of mild reaction conditions, high reaction efficiency, and feasibility of scalable synthesis, providing a facile and sustainable route to diverse indenones.
FeCl3 mediated synthesis of substituted indenones by a formal [2+2] cycloaddition/ring opening cascade of o-keto-cinnamates
Dethe, Dattatraya H.,Murhade, Ganesh M.
supporting information, p. 10891 - 10894 (2015/06/30)
A novel FeCl3 mediated formal [2+2] cycloaddition/ring opening cascade of o-keto-cinnamates was developed for the synthesis of indenones. The reaction tolerates a broad range of functional groups, including bromide, chloride, amide, acid and es
Indenone derivatives: A novel template for peroxisome proliferator- activated receptor γ (PPARγ) agonists
Ahn, Jin Hee,Shin, Mi Sik,Jung, Sun Ho,Kang, Seung Kyu,Kim, Kwang Rok,Rhee, Sang Dal,Jung, Won Hoon,Yang, Sung Don,Kim, Seung Jun,Woo, Joo Rang,Lee, Jeong Hyung,Cheon, Hyae Gyeong,Kim, Sung Soo
, p. 4781 - 4784 (2007/10/03)
Agonists of peroxisome proliferator-activated receptor γ(PPAR γ) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR γ agonist. Moreover, compound 14c has displayed the most active agonistic activi
