867334-05-2

Basic information

• Product Name: Phenol, 4-chloro-3-[5-Methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-1,2,4-benzotriazin-7-yl]-
• Synonyms: Phenol, 4-chloro-3-[5-Methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-1,2,4-benzotriazin-7-yl]-;TG 100572;4-Chloro-3-[5-methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-1,2,4-benzotriazin-7-yl]phenol;4-Chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenol
• CAS NO: 867334-05-2
• Molecular Formula: C₂₆H₂₆ClN₅O₂
• Molecular Weight: 475.96994
• Mol File: 867334-05-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 683.5±65.0 °C(Predicted)
• Appearance: /
• Density: 1.331±0.06 g/cm3(Predicted)
• PKA: 8.82±0.18(Predicted)
• CAS DataBase Reference: Phenol, 4-chloro-3-[5-Methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-1,2,4-benzotriazin-7-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-chloro-3-[5-Methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-1,2,4-benzotriazin-7-yl]-(867334-05-2)
• EPA Substance Registry System: Phenol, 4-chloro-3-[5-Methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-1,2,4-benzotriazin-7-yl]-(867334-05-2)

Safety Data

• Hazardous Substances Data: 867334-05-2(Hazardous Substances Data)

Usage

Uses

TG 100572 is a Src kinase inhibitor.

Upstream product

• 867331-09-7 3-(3-amino-5-methyl-benzo[1,2,4]triazin-7-yl)-4-chloro-phenol 
• 1081-73-8 1-[2-(4-bromophenoxy)ethyl]pyrrolidine 
• 867331-63-3 7-(2-chloro-5-methoxyphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-ylamine 

Downstream Products

• 1018070-95-5 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl N-tert-butyloxycarbonyl glycinate 
• 1018070-18-2 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl 4-(morpholin-4-ylmethyl)benzoate 
• 1018070-13-7 C₃₃H₂₈Cl₃N₅O₃ 
• 1018070-07-9 C₃₅H₃₄ClN₅O₃ 

Relevant articles and documents

Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy) phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): A topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degene

Age-related macular degeneration (AMD) is one of the leading causes of loss of vision in the industrialized world. Attenuating the VEGF signal in the eye to treat AMD has been validated clinically. A large body of evidence suggests that inhibitors targeti