869101-36-0Relevant articles and documents
RCM for the construction of novel steroid-like polycyclic systems. 1. Studies on the synthesis of a PreD3-D3 transition state analogue
Garcia-Fandino, Rebeca,Aldegunde, Maria Jose,Codesido, Eva M.,Castedo, Luis,Granja, Juan R.
, p. 8281 - 8290 (2007/10/03)
Natural and nonnatural polycyclic systems containing eight-membered carbocycles constitute a large class of compounds of importance in organic chemistry, biology, and medicine. Here we describe a new strategy by which complex polycyclic steroid-like systems can be constructed on the steroid CD framework, by a combination of RCM and Heck cyclizations. The method is exemplified by its application to the stereoselective synthesis of 6-8-6 fused carbocyclic systems that mimic the putative transition structure of the isomerization of previtamin D3 to vitamin D3.