869194-33-2

Basic information

• Product Name: 4-benzyl-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one
• Synonyms: 4-benzyl-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one
• CAS NO: 869194-33-2
• Molecular Weight: 261.323
• Mol File: 869194-33-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-benzyl-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one(869194-33-2)
• EPA Substance Registry System: 4-benzyl-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one(869194-33-2)

Safety Data

• Hazardous Substances Data: 869194-33-2(Hazardous Substances Data)

Upstream product

• 62136-38-3 (1E/Z)-cyclopentane-1,2-dione phenylhydrazome 
• 16244-15-8 1,4-dihydrocyclopenta[b]indol-3(2H)-one 
• 100-44-7 benzyl chloride 

Relevant articles and documents

Stereoselective formation of carbon-carbon bonds via SN2- displacement: Synthesis of substituted cycloalkyl[b]indoles

A general asymmetric synthesis of substituted cycloalkyl[b]indoles has been accomplished. The key features of this approach are (1) the utilization of a Japp-Klingemann condensation/Fischer cyclization to prepare cycloalkyl[b] indolones, (2) the asymmetric borane reduction of these heterocyclic ketones with (S)-OAB to obtain enantiomerically pure alcohols, and (3) the stereoselective SN2-displacement of these indole alcohol substrates with a carbon nucleophile under Mitsunobu conditions to set the C1 or C3 tertiary carbon stereocenter. The use of trimethylphosphine (PMe3) and bis(2,2,2-trichloroethyl) azodicarboxylate (TCEAD) was found to have an effect on the Mitsunobu dehydrative alkylation.