16244-15-8

Basic information

• Product Name: 1,2-dihydrocyclopenta[b]indol-3(4H)-one
• Synonyms: 1,2-dihydrocyclopenta[b]indol-3(4H)-one;1,4-Dihydro-2H-cyclopenta[b]indol-3-one
• CAS NO: 16244-15-8
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.19526
• Mol File: 16244-15-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 228-230 °C (decomp)
• Boiling Point: 366.2°C at 760 mmHg
• Flash Point: 182.9°C
• Appearance: /
• Density: 1.343g/cm³
• Vapor Pressure: 1.49E-05mmHg at 25°C
• Refractive Index: 1.729
• PKA: 15.09±0.20(Predicted)
• CAS DataBase Reference: 1,2-dihydrocyclopenta[b]indol-3(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dihydrocyclopenta[b]indol-3(4H)-one(16244-15-8)
• EPA Substance Registry System: 1,2-dihydrocyclopenta[b]indol-3(4H)-one(16244-15-8)

Safety Data

• Hazardous Substances Data: 16244-15-8(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Structure

Bicyclic structure

Usage

Building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds

Biological activities

Antifungal, antioxidant, and anticancer properties

Potential use

Precursor in the development of new drugs

Importance

Significant in the field of organic chemistry

Applications

Promising in the pharmaceutical industry

InChI:InChI=1/C11H9NO/c13-10-6-5-8-7-3-1-2-4-9(7)12-11(8)10/h1-4,12H,5-6H2

Upstream product

• 830-96-6 Indole-3-propionic acid 
• 62136-38-3 (1E/Z)-cyclopentane-1,2-dione phenylhydrazome 
• 2047-91-8 2,3-dihydro-1H-cyclopentindole 
• 1192-54-7 2-formylcyclopentanone 
• 62-53-3 aniline 
• 7664-93-9 sulfuric acid 
• 100-34-5 benzene diazonium chloride 
• 120-92-3 cyclopentanone 
• 91034-57-0 (Z)-2-(hydroxymethylene)cyclopentan-1-one 
• 1449650-46-7 (Z)-2-(2-phenylhydrazono)cyclopentan-1-one 

Downstream Products

• 441067-91-0 2-(4'-methoxy)-benzylidineindolo[2,3-b]cyclopentan-1-one 
• 869194-33-2 4-benzyl-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-one 
• 869194-38-7 (3R)-4-benzyl-1,2,3,4-tetrahydrocyclopenta[b]indol-3-ol 
• 142284-23-9 4-Methyl-3-[(E)-phenethylimino]-1,2,3,4-tetrahydro-cyclopenta[b]indol-7-ol 

Relevant articles and documents

Design, synthesis and antiproliferative activity of indole analogues of indanocine

The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative activity in the NCI's panel of cancer cell lines. Indanocine displays potent activity against a wide range of cancer cell lines

A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability

Aurora kinase inhibitors have attracted a great deal of interest as a new class of antimitotic agents. We report a novel class of Aurora inhibitors based on a pentacyclic scaffold. A prototype pentacyclic inhibitor 32 (AKI-001) derived from two early lead

Synthesis of 1-indanones by intramolecular Friedel-Crafts reaction of 3-arylpropionic acids catalyzed by Tb(OTf)3

Intramolecular Friedel-Crafts acylation reaction of 3-arylpropionic acids was efficiently catalyzed by Tb(OTf)3 at 250°C to give 1-indanones. Even deactivated 3-arylpropionic acids with halogen atoms on the aromatic ring can be cyclized in moderation to good yields.