870007-53-7

Basic information

• Product Name: (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole
• Synonyms: (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole
• CAS NO: 870007-53-7
• Molecular Weight: 467.438
• Mol File: 870007-53-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole(870007-53-7)
• EPA Substance Registry System: (4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dihydro-1H-imidazole(870007-53-7)

Safety Data

• Hazardous Substances Data: 870007-53-7(Hazardous Substances Data)

Upstream product

• 870007-39-9 4-(tert-butyl)-2-ethoxy-benzoic acid methyl ester 
• 86212-34-2 (1R,2S)-1,2-bis(4-chlorophenyl)ethane-1,2-diamine 
• 870007-40-2 4-tert-butyl-2-ethoxy-1-iodo-benzene 
• 585-34-2 3-tert-butylphenyol 
• 20942-70-5 2-iodo-5-(1,1-dimethylethyl)phenol 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 870120-40-4 2-{4-[(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-morpholin-4-yl-ethanone 
• 870007-79-7 2-{4-[(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-1-morpholin-4-yl-ethanone hydrochloride 

Relevant articles and documents

MDM2 DEGRADERS AND USES THEREOF

The present invention relates to compounds and methods useful for the modulation of mouse double minute 2 homolog ("MDM2") protein via ubiquitination and/or degradation by compounds according to the present invention.

NOVEL CIS-IMIDAZOLINES

Formula (I) and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3,Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proiferative activity.