870837-21-1

Basic information

• Product Name: METHYL 3-METHOXY-4-(4-METHYL-1-IMIDAZOLYL)BENZOATE
• Synonyms: METHYL 3-METHOXY-4-(4-METHYL-1-IMIDAZOLYL)BENZOATE;methyl 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoate;3-METHOXY-4-(4-METHYL-IMIDAZOL-1-YL)-BENZOIC ACID METHYL ESTER;Benzoic acid, 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-, methyl ester
• CAS NO: 870837-21-1
• Molecular Formula: C₁₃H₁₄N₂O₃
• Molecular Weight: 246.26
• Mol File: 870837-21-1.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 3-METHOXY-4-(4-METHYL-1-IMIDAZOLYL)BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-METHOXY-4-(4-METHYL-1-IMIDAZOLYL)BENZOATE(870837-21-1)
• EPA Substance Registry System: METHYL 3-METHOXY-4-(4-METHYL-1-IMIDAZOLYL)BENZOATE(870837-21-1)

Safety Data

• Hazardous Substances Data: 870837-21-1(Hazardous Substances Data)

Usage

General Description

Methyl 3-methoxy-4-(4-methyl-1-imidazolyl)benzoate is a chemical compound with the molecular formula C16H16N2O3. It is an ester of benzoic acid and is commonly used in the fragrance and flavor industries. METHYL 3-METHOXY-4-(4-METHYL-1-IMIDAZOLYL)BENZOATE has a benzene ring with a methoxy group and a methyl-imidazolyl group attached, providing unique aromatic properties. It is often utilized as a flavoring agent in food and beverages, as well as in the production of perfumes and cosmetics. Additionally, it may also have pharmaceutical applications due to its aromatic and functional properties.

Upstream product

• 870837-20-0 4-[formyl-(2-oxopropyl)amino]-3-methoxybenzoic acid methyl ester 
• 64248-62-0 3,4-Difluorobenzonitrile 
• 243128-37-2 4-fluoro-3-methoxybenzonitrile 
• 67-56-1 methanol 
• 1243204-92-3 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzonitrile 
• 1280150-10-8 3-fluoro-4-(4-methyl-1H-imidazol-1-yl)benzonitrile 
• 822-36-6 4-methyl-1H-imidazole 
• 175153-75-0 3-methoxy-4-trifluoromethane-sulfonyloxy-benzoic acid methyl ester 
• 41608-64-4 methyl 3-methoxy-4-aminobenzoate 
• 700834-18-0 4-formylamino-3-methoxybenzoic acid methyl ester 
• 5081-37-8 methyl 3-methoxy-4-nitrobenzoate 
• 619-14-7 3-hydroxy-4-nitro-benzoic acid 

Downstream Products

• 870837-18-6 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde 
• 937026-26-1 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzoic acid 
• 1242314-39-1 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzohydrazide 
• 1262106-88-6 tert-butyl 2-{[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]carbonyl}hydrazinecarboxylate 
• 1363145-33-8 ethyl 8-(3,4-difluorophenyl)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 1363146-39-7 ethyl 3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 1363146-44-4 ethyl 8-chloro-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 870850-40-1 (E)-1-(4-(2-carboxy-5-chloropent-1-en-1-yl)-2-methoxyphenyl)-4-methyl-1H-imidazol-3-ium 2,2,2-trifluoroacetate 
• 870843-26-8 tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate 
• 1352130-00-7 (S,E)-5-chloro-N-(2-hydroxy-1-(3,4,5-trifluorophenyl)ethyl)-2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)pentanamide 
• 870852-75-8 (S,E)-1-(2-hydroxy-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one 
• 1352130-01-8 (S,E)-1-(2-(aminooxy)-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one 
• 870839-41-1 (E)-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid 
• 870837-70-0 4-(1H-imidazol-1-yl)-3-methoxybenzaldehyde 

Relevant articles and documents

Synthesis of the γ-Secretase Modulator MK-8428

The synthesis of the γ-secretase modulator MK-8428 (1) is described. The synthesis is highlighted by an enzyme-catalyzed reaction to access 3,4,5-trifluoro-(S)-phenylglycine, a 1-pot activation/displacement/deprotection sequence to introduce the aminooxy functionality and a dehydrative intramolecular cyclization under mild conditions to form the oxadiazine heterocycle of 1. In situ reaction monitoring was employed to understand the deleterious role of water during the formation of a methanesulfonate ester in the 1-pot activation/displacement/deprotection sequence.

Completely N1-selective palladium-catalyzed arylation of unsymmetric imidazoles: Application to the synthesis of nilotinib

The completely N1-selective Pd-catalyzed arylation of unsymmetric imidazoles with aryl halides and triflates is described. This study showed that imidazoles have a strong inhibitory effect on the in situ formation of the catalytically active Pd(0)-ligand complex. The efficacy of the N-arylation reaction was improved drastically by the use of a preactivated solution of Pd2(dba)3 and L1. From these findings, it is clear that while imidazoles can prevent binding of L1 to Pd, once the ligand is bound to the metal, these heterocycles do not displace it. The utility of the present catalytic system was demonstrated by the regioselective synthesis of the clinically important tyrosine kinase inhibitor nilotinib.

UREA TYPE CINNAMIDE DERIVATIVE

Disclosed is a compound represented by the formula (I) below or a pharmacologically acceptable salt thereof. Also disclosed is a use of the compound or salt as a pharmaceutical product. (In the formula, Ar1 represents an imidazolyl group which may be substituted with a C1-6 alkyl group; Ar2 represents a phenyl group which may be substituted with a C1-6 alkoxy group; X1 represents a single bond; R1 and R2 respectively represent a C1-6 alkyl group or the like which may be substituted with a substituent such as a 5- to 14-membered aromatic heterocyclic group; and R3 represents a hydrogen atom or the like.)