870852-75-8

Basic information

• Product Name: 2-Piperidinone, 1-[(1S)-2-hydroxy-1-(3,4,5-trifluorophenyl)ethyl]-3-[[3-methoxy-4-(4-meth yl-1H-imidazol-1-yl)phenyl]methylene]-, (3E)-
• CAS NO: 870852-75-8
• Molecular Formula: C25H24F3N3O3
• Molecular Weight: 471.479
• Mol File: 870852-75-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Piperidinone, 1-[(1S)-2-hydroxy-1-(3,4,5-trifluorophenyl)ethyl]-3-[[3-methoxy-4-(4-meth yl-1H-imidazol-1-yl)phenyl]methylene]-, (3E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidinone, 1-[(1S)-2-hydroxy-1-(3,4,5-trifluorophenyl)ethyl]-3-[[3-methoxy-4-(4-meth yl-1H-imidazol-1-yl)phenyl]methylene]-, (3E)-(870852-75-8)
• EPA Substance Registry System: 2-Piperidinone, 1-[(1S)-2-hydroxy-1-(3,4,5-trifluorophenyl)ethyl]-3-[[3-methoxy-4-(4-meth yl-1H-imidazol-1-yl)phenyl]methylene]-, (3E)-(870852-75-8)

Safety Data

• Hazardous Substances Data: 870852-75-8(Hazardous Substances Data)

Upstream product

• 1022990-86-8 (S)-2-amino-2-(3,4,5-trifluorophenyl)acetic acid 
• 138526-69-9 3,4,5-trifluoro-1-bromobenzene 
• 870843-26-8 tert-butyl 5-chloro-2-{1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-(E)-methylidene}valerate 
• 870843-25-7 5-chloro-2-(diethoxyphosphoryl)valeric acid tert-butyl ester 
• 870837-18-6 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde 
• 870837-21-1 3-methoxy-4-(4-methylimidazol-1-yl)benzoic acid methyl ester 
• 870850-40-1 (E)-1-(4-(2-carboxy-5-chloropent-1-en-1-yl)-2-methoxyphenyl)-4-methyl-1H-imidazol-3-ium 2,2,2-trifluoroacetate 
• 870837-20-0 4-[formyl-(2-oxopropyl)amino]-3-methoxybenzoic acid methyl ester 
• 41608-64-4 methyl 3-methoxy-4-aminobenzoate 
• 5081-37-8 methyl 3-methoxy-4-nitrobenzoate 
• 1352130-00-7 (S,E)-5-chloro-N-(2-hydroxy-1-(3,4,5-trifluorophenyl)ethyl)-2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)pentanamide 
• 1213556-08-1 (S)-2-amino-2-(3,4,5-trifluorophenyl)ethanol 
• 1367361-09-8 C₁₆H₁₄F₃NO₃ 
• 159294-99-2 1,2,3-trifluoro-5-vinylbenzene 

Downstream Products

• 1352130-01-8 (S,E)-1-(2-(aminooxy)-1-(3,4,5-trifluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one 
• 1352130-02-9 (S,E)-9-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-benzylidene)-4-(3,4,5-trifluorophenyl)-3,4,6,7,8,9-hexahydropyrido[2,1-c][1,2,4]oxadiazine 

Relevant articles and documents

Synthesis of the γ-Secretase Modulator MK-8428

The synthesis of the γ-secretase modulator MK-8428 (1) is described. The synthesis is highlighted by an enzyme-catalyzed reaction to access 3,4,5-trifluoro-(S)-phenylglycine, a 1-pot activation/displacement/deprotection sequence to introduce the aminooxy functionality and a dehydrative intramolecular cyclization under mild conditions to form the oxadiazine heterocycle of 1. In situ reaction monitoring was employed to understand the deleterious role of water during the formation of a methanesulfonate ester in the 1-pot activation/displacement/deprotection sequence.