87171-25-3

Basic information

• Product Name: Ethanone, 1-[4-(aminomethyl)phenyl]- (9CI)
• Synonyms: Ethanone, 1-[4-(aminomethyl)phenyl]- (9CI);1-(4-(aminomethyl)phenyl)ethanone;Ethanone, 1-[4-(aminomethyl)phenyl];1-[4-(aminomethyl)phenyl]ethanone hydrochloride
• CAS NO: 87171-25-3
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.18974
• Product Categories: ACETYLGROUP
• Mol File: 87171-25-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethanone, 1-[4-(aminomethyl)phenyl]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[4-(aminomethyl)phenyl]- (9CI)(87171-25-3)
• EPA Substance Registry System: Ethanone, 1-[4-(aminomethyl)phenyl]- (9CI)(87171-25-3)

Safety Data

• Hazardous Substances Data: 87171-25-3(Hazardous Substances Data)

Usage

Description

Ethanone, 1-[4-(aminomethyl)phenyl](9CI) is an organic compound that features a unique structure consisting of an ethanone (acetone) moiety attached to a phenyl ring with an aminomethyl group at the para position. Ethanone, 1-[4-(aminomethyl)phenyl](9CI) is characterized by its ability to participate in various chemical reactions and has potential applications in different fields due to its distinct chemical properties.

Uses

Used in Pharmaceutical and Biochemical Research:
Ethanone, 1-[4-(aminomethyl)phenyl](9CI) is utilized as a key intermediate in the synthesis of various pharmaceutical compounds and bioactive molecules. Its presence in the structure allows for the development of new drugs with potential therapeutic applications.
Used in Structure-Function Studies:
In the field of enzymology, Ethanone, 1-[4-(aminomethyl)phenyl](9CI) is employed in structure-function studies of substrate oxidation by bovine serum amine oxidase. This application aids researchers in understanding the enzyme's mechanism of action and its role in biological processes.
Used in Chemical Synthesis:
Ethanone, 1-[4-(aminomethyl)phenyl](9CI) serves as a versatile building block in organic synthesis, enabling the creation of a wide range of chemical compounds. Its reactivity and functional groups make it suitable for various synthetic routes, leading to the production of target molecules with specific properties and applications.
Used in Analytical Chemistry:
Ethanone, 1-[4-(aminomethyl)phenyl](9CI) can also be used in analytical chemistry as a reference material or standard for the development and validation of analytical methods. Its unique structure and properties make it a valuable tool for assessing the performance of chromatographic, spectroscopic, and other analytical techniques.

Upstream product

• 99-91-2 para-chloroacetophenone 
• 7441-43-2 4-ethylbenzylamine 
• 1443-80-7 4-cyanophenyl methyl ketone 

Downstream Products

• 91991-67-2 1-{4-[(6-Amino-5-nitro-pyridin-2-ylamino)-methyl]-phenyl}-ethanone 
• 1039454-77-7 N-(4-acetylbenzyl)benzamide 
• 1443-80-7 4-cyanophenyl methyl ketone 
• 1263183-81-8 N-1-(4-(((4-acetylbenzyl)imino)methyl)phenyl)ethan-1-one 
• 7441-43-2 4-ethylbenzylamine 

Relevant articles and documents

A cobalt phosphide catalyst for the hydrogenation of nitriles

The study of metal phosphide catalysts for organic synthesis is rare. We present, for the first time, a well-defined nano-cobalt phosphide (nano-Co2P) that can serve as a new class of catalysts for the hydrogenation of nitriles to primary amines. While earth-abundant metal catalysts for nitrile hydrogenation generally suffer from air-instability (pyrophoricity), low activity and the need for harsh reaction conditions, nano-Co2P shows both air-stability and remarkably high activity for the hydrogenation of valeronitrile with an excellent turnover number exceeding 58000, which is over 20- to 500-fold greater than that of those previously reported. Moreover, nano-Co2P efficiently promotes the hydrogenation of a wide range of nitriles, which include di- and tetra-nitriles, to the corresponding primary amines even under just 1 bar of H2 pressure, far milder than the conventional reaction conditions. Detailed spectroscopic studies reveal that the high performance of nano-Co2P is attributed to its air-stable metallic nature and the increase of the d-electron density of Co near the Fermi level by the phosphidation of Co, which thus leads to the accelerated activation of both nitrile and H2. Such a phosphidation provides a promising method for the design of an advanced catalyst with high activity and stability in highly efficient and environmentally benign hydrogenations. This journal is

Remote C(sp3)-H Oxygenation of Protonated Aliphatic Amines with Potassium Persulfate

This letter describes the development of a method for selective remote C(sp3)-H oxygenation of protonated aliphatic amines using aqueous potassium persulfate. Protonation serves to deactivate the proximal C(sp3)-H bonds of the amine substrates and also renders the amines soluble in the aqueous medium. These reactions proceed under relatively mild conditions (within 2 h at 80 °C with amine as limiting reagent) and do not require a transition metal catalyst. This method is applicable to a variety of types of C(sp3)-H bonds, including 3°, 2°, and benzylic C-H sites in primary, secondary, and tertiary amine substrates.

One-pot primary aminomethylation of aryl and heteroaryl halides with sodium phthalimidomethyltrifluoroborate

A one-pot primary aminomethylation of aryl halides, triflates, mesylates, and tosylates via Suzuki-Miyaura cross-coupling reactions with sodium phthalimidomethyltrifluoroborate followed by deamidation with ethylenediamine is reported.