872599-17-2

Basic information

• Product Name: Silane, (1,1-dimethylethyl)(4-isothiocyanatophenoxy)dimethyl-
• CAS NO: 872599-17-2
• Molecular Formula: C13H19NOSSi
• Molecular Weight: 265.451
• Mol File: 872599-17-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Silane, (1,1-dimethylethyl)(4-isothiocyanatophenoxy)dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, (1,1-dimethylethyl)(4-isothiocyanatophenoxy)dimethyl-(872599-17-2)
• EPA Substance Registry System: Silane, (1,1-dimethylethyl)(4-isothiocyanatophenoxy)dimethyl-(872599-17-2)

Safety Data

• Hazardous Substances Data: 872599-17-2(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 123-30-8 4-amino-phenol 
• 463-71-8 thiophosgene 
• 111359-74-1 4-[(tert-butyldimethylsilyl)oxy]aniline 

Downstream Products

• 872599-18-3 1-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-thiourea 

Relevant articles and documents

New prodrugs derived from 6-aminodopamine and 4-aminophenol as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT)

Two novel tyrosinase mediated drug delivery pathways have been investigated for the selective delivery of cytotoxic units to melanocytes from urea and thiourea prodrugs. The synthesis of these prodrugs is reported, as well as oximetry data that illustrate that the targets are substrates for tyrosinase. The stability of each of the prodrugs in (i) phosphate buffer and (ii) bovine serum is discussed, and the urea prodrugs are identified as lead candidates for further studies. Finally, HPLC studies and preliminary cytotoxicity studies in a melanotic and an amelanotic cell line, that illustrate the feasibility of the approach, are presented. The Royal Society of Chemistry 2005.