872703-52-1

Basic information

• Product Name: Benzenepropanamide, N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-a-methylene-
• CAS NO: 872703-52-1
• Molecular Formula: C19H19NO2
• Molecular Weight: 293.365
• Mol File: 872703-52-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenepropanamide, N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-a-methylene-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanamide, N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-a-methylene-(872703-52-1)
• EPA Substance Registry System: Benzenepropanamide, N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-a-methylene-(872703-52-1)

Safety Data

• Hazardous Substances Data: 872703-52-1(Hazardous Substances Data)

Upstream product

• 7480-35-5 (1S,2R)-1-amino-2-indanol 
• 5669-19-2 2-Benzyl-2-propenoic acid 

Downstream Products

• 872703-69-0 1 
• 872703-72-5 (2S)-2-benzyl-oxirane-N-[(1S,2R)-2-hydroxy-indan-1-yl]-2-carboxylic acid amide 
• 872703-73-6 (2R)-2-benzyl-oxirane-N-[(1S,2R)-2-hydroxy-indan-1-yl]-2-carboxylic acid amide 

Relevant articles and documents

Discovery of potent HIV-1 protease inhibitors incorporating sulfoximine functionality

Based on the unique property of sulfoximine and the homodimeric C2 structural symmetry of HIV-1 protease, a novel class of sulfoximine-based pseudosymmetric HIV-1 protease inhibitors was designed and synthesized. The sulfoximine moiety was demonstrated to be important for HIV-1 protease inhibitor potency. The most active stereoisomer (2S,2′S) displays a potency of 2.5 nM (IC50) against HIV-1 protease and an anti-HIV-1 activity of 408 nM (IC50). A possible mode of action is proposed.

A new class of HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold

Novel HIV-1 protease inhibitors encompassing a tertiary alcohol as part of the transition-state mimicking unit have been synthesized. Variation of the P1′-P3′ residues and alteration of the tertiary alcohol absolute stereochemistry a