872703-69-0

Basic information

• Product Name: L-Valine, N-(methoxycarbonyl)-3-methyl-, 2-[(4-bromophenyl)methyl]-2-[(2S)-3-[[(1S,2R)-2,3-dihydro-2-hydroxy-1 H-inden-1-yl]amino]-2-hydroxy-3-oxo-2-(phenylmethyl)propyl]hydrazide
• CAS NO: 872703-69-0
• Molecular Formula: C34H41BrN4O6
• Molecular Weight: 681.627
• Mol File: 872703-69-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Valine, N-(methoxycarbonyl)-3-methyl-, 2-[(4-bromophenyl)methyl]-2-[(2S)-3-[[(1S,2R)-2,3-dihydro-2-hydroxy-1 H-inden-1-yl]amino]-2-hydroxy-3-oxo-2-(phenylmethyl)propyl]hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valine, N-(methoxycarbonyl)-3-methyl-, 2-[(4-bromophenyl)methyl]-2-[(2S)-3-[[(1S,2R)-2,3-dihydro-2-hydroxy-1 H-inden-1-yl]amino]-2-hydroxy-3-oxo-2-(phenylmethyl)propyl]hydrazide(872703-69-0)
• EPA Substance Registry System: L-Valine, N-(methoxycarbonyl)-3-methyl-, 2-[(4-bromophenyl)methyl]-2-[(2S)-3-[[(1S,2R)-2,3-dihydro-2-hydroxy-1 H-inden-1-yl]amino]-2-hydroxy-3-oxo-2-(phenylmethyl)propyl]hydrazide(872703-69-0)

Safety Data

• Hazardous Substances Data: 872703-69-0(Hazardous Substances Data)

Upstream product

• 872703-59-8 {(1S)-1-[N'-(4-bromobenzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl}carbamic acid methyl ester 
• 872703-72-5 (2S)-2-benzyl-oxirane-N-[(1S,2R)-2-hydroxy-indan-1-yl]-2-carboxylic acid amide 
• 5669-19-2 2-Benzyl-2-propenoic acid 
• 7480-35-5 (1S,2R)-1-amino-2-indanol 
• 872703-52-1 2-benzyl-N-[(1S,2R)-2-hydroxy-indan-1-yl]acrylamide 
• 162537-11-3 (S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid 

Relevant articles and documents

Microwave-accelerated synthesis of P1′-extended HIV-1 protease inhibitors encompassing a tertiary alcohol in the transition-state mimicking scaffold

Two series of P1′-extended HIV-1 protease inhibitors comprising a tertiary alcohol in the transition-state mimic exhibiting Ki values ranging from 2.1 to 93 nM have been synthesized. Microwave-accelerated palladium-catalyzed cross-couplings were utilized to rapidly optimize the P1′ side chain. High cellular antiviral potencies were encountered when the P1′ benzyl group was elongated with a 3- or 4-pyridyl substituent (EC50 = 0.18-0.22 μM). X-ray crystallographic data were obtained for three inhibitors cocrystallized with the enzyme.

A new class of HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold

Novel HIV-1 protease inhibitors encompassing a tertiary alcohol as part of the transition-state mimicking unit have been synthesized. Variation of the P1′-P3′ residues and alteration of the tertiary alcohol absolute stereochemistry a