872726-44-8

Basic information

• Product Name: GW 610
• Synonyms: GW 610;NSC 721648
• CAS NO: 872726-44-8
• Molecular Formula: C₁₅H₁₂FNO₂S
• Molecular Weight: 289.3246832
• Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 872726-44-8.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: +2C to +8C
• CAS DataBase Reference: GW 610(CAS DataBase Reference)
• NIST Chemistry Reference: GW 610(872726-44-8)
• EPA Substance Registry System: GW 610(872726-44-8)

Safety Data

• Hazardous Substances Data: 872726-44-8(Hazardous Substances Data)

Usage

Description

GW 610 is an antitumor benzothiazole that exhibits growth-inhibitory activity against various cancer cell lines, particularly breast, lung, and colon cancer. It demonstrates potent antiproliferative activity in MCF-7 and MDA 468 human cancer cell lines, with GI50 values less than 0.1 nM. GW 610's antitumor activity is not dependent on the induction of cytochrome P 1A1 (CYP1A1) expression.

Uses

Used in Pharmaceutical Industry:
GW 610 is used as a potential antitumor drug for its potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Its species-specific partial agonism of the aryl hydrocarbon receptor plays a significant role in its anti-proliferative activity, making it a promising candidate for cancer treatment.

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Relevant articles and documents

Recyclable copper-catalyzed cyclization of o-haloanilides and metal sulfides: An efficient and practical access to substituted benzothiazoles

An efficient heterogeneous copper-catalyzed cyclization of o-haloanilides and metal sulfides has been achieved via the C–S coupling in DMF at 80 or 140 °C in the existence of an MCM-41-bound NHC-Cu(I) catalyst and then intramolecular condensation, delivering a wide range of substituted benzothiazoles in mostly good to high yields. This new MCM-41-NHC-CuI complex can facilely be obtained by a two-step procedure starting from easily accessible and inexpensive reagents and reused more than seven times without any significant loss of its catalytic efficiency. The present protocol has been successfully applied to the gram-scale synthesis of two antitumor agents 5F203 and PMX 610.

Method for preparing benzothiazole compound from visible light promoted N-(2-bromophenyl) thioamide

The invention discloses a method for preparing a benzothiazole compound from N-(2-bromophenyl) thioamide under the promotion of visible light. Specifically, under the protection of inert gas, according to the molar ratio of N-(2-bromophenyl) thioamide to inorganic base being 1: 0.5, reactants are added into a reaction container provided with a stirring device, then dimethyl sulfoxide is added, and stirring reaction is carried out for 2-24 hours at room temperature under the irradiation of visible light to obtain the benzothiazole compound. Under the condition of not adding any photosensitizer or transition metal catalyst, sodium phosphate is used as alkali, and under the irradiation of a 45W household compact fluorescent lamp, a series of intramolecular cross-coupling reactions of N-(2-bromophenyl) thioamide are realized. In addition, the benzothiazole compound can be obtained with high yield. The whole process is green, efficient and easy to operate, and the method is a good method for synthesizing the benzothiazole compound.

Elemental Sulfur-Mediated Decarboxylative Redox Cyclization Reaction: Copper-Catalyzed Synthesis of 2-Substituted Benzothiazoles

A S 8 -mediated directed decarboxylative redox-cyclization strategy for the synthesis of 2-substituted benzothiazoles from o -iodoanilines, arylacetic acids, and elemental sulfur catalyzed by cheap copper metal has been developed. This reaction is operationally simple, ligand-free, compatible with a wide range of functional groups, and provides the desired products in good to excellent yields. In addition, a gram-scale experiment was carried out to furnish PMX 610, an antitumor drug.