87338-04-3

Basic information

• Product Name: 2-Bromo-1,1-dimethoxy-1-(4-chlorophenyl)propane
• Synonyms: 2-Bromo-1,1-dimethoxy-1-(4-chlorophenyl)propane
• CAS NO: 87338-04-3
• Molecular Weight: 293.588
• Mol File: 87338-04-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Bromo-1,1-dimethoxy-1-(4-chlorophenyl)propane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-1,1-dimethoxy-1-(4-chlorophenyl)propane(87338-04-3)
• EPA Substance Registry System: 2-Bromo-1,1-dimethoxy-1-(4-chlorophenyl)propane(87338-04-3)

Safety Data

• Hazardous Substances Data: 87338-04-3(Hazardous Substances Data)

Upstream product

• 877-37-2 2-bromo-1-(4-chlorophenyl)-1-propanone 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 50415-70-8 methyl 2-(p-chlorophenyl)propionate 

Relevant articles and documents

A Lewis Acid Catalyzed 1,2 Aryl Shift in α-Haloalkyl Aryl Acetals: A Convenient Route to α-Arylalkanoic Acids

A new method for the synthesis of α-arylalkanoic acids is given, based on Lewis acid promoted rearrangement of acetals of primary and secondary α-haloalkyl aryl ketones (halo = Br, Cl) in hydrocarbon solvents.The reaction is selective, providing the esters of α-arylalkanoic acids in almost quantitative yields.The ability of "soft and borderline" Lewis acids in activating the carbon-halogen bond is compared with that of silver salts.The reaction mechanism is discussed.The present synthesis has been applied to some α-arylpropionic acids well-known as antiinflammatory drugs.