873945-31-4

Basic information

• Product Name: 3-Hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidine
• Synonyms: 3-Hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidine;(3R,4R,5S)-4-(4-Hydroxyphenyl)-5-(triisopropylsilanyloxy)piperidin-3-ol;(3R,4R,5S)-4-(4-Hydroxyphenyl)-5-[[tris(1-methylethyl)silyl]oxy]-3-piperidinol;(3R,4R,5S)-4-(4-Hydroxyphenyl)-5-((triisopropyl-silyl)oxy)piperidin-3-ol
• CAS NO: 873945-31-4
• Molecular Formula: C₂₀H₃₅NO₃Si
• Molecular Weight: 365.5823
• Mol File: 873945-31-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.05
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidine(873945-31-4)
• EPA Substance Registry System: 3-Hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidine(873945-31-4)

Safety Data

• Hazardous Substances Data: 873945-31-4(Hazardous Substances Data)

Usage

General Description

3-Hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidine is a chemical compound that belongs to the class of piperidine derivatives. It is composed of a piperidine ring with a hydroxy and a triisopropylsilyloxy substituent at the 3 and 5 positions, and a phenyl ring with a hydroxy group at the 4 position. 3-Hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidine has potential biological and pharmaceutical applications, as it may exhibit activity as a pharmaceutical agent or a precursor in organic synthesis. Its unique structure and functional groups make it a valuable compound for further research and development in the field of medicinal chemistry and drug discovery.

Upstream product

• 873945-33-6 (3R,4R,5S)-4-(4-benzyloxy-phenyl)-1-((R)-1-phenyl-ethyl)-5-triisopropylsilanyloxy-piperidin-3-ol 
• 257928-45-3 (3R,4R,5S)-4-(4-benzyloxyphenyl)-1-(1-phenylethyl)-5-triisopropylsilanyloxy-piperidin-3-ol 

Downstream Products

• 873945-27-8 (3R,4R,5S)-3-hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyl-oxy-piperidine-1-carboxylic acid benzyl ester 
• 944952-84-5 (3R,4R,5S)-4-(4-hydroxyphenyl)-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxypiperidin-3-ol 
• 912346-39-5 benzyl (3R,4R,5S)-3-hydroxy-5-triisopropylsilanyloxy-4-(4-vinylphenyl)-piperidine-1-carboxylate 
• 873946-14-6 benzyl (3R,4R,5S)-3-hydroxy-4-(4-methoxycarbonylphenyl)-5-triisopropylsilanyl-oxypiperidine-1-carboxylate 
• 912346-47-5 (3R,4R,5S)-4-(4-allyloxy-phenyl)-3-hydroxy-5-triisopropylsilanyloxy-piperidine-1-carboxylic acid benzyl ester 
• 873946-15-7 benzyl (3R,4R,5S)-3-hydroxy-4-(4-trifluoromethanesulphonyloxyphenyl)-5-triisopropylsilanyloxy-piperidine-1-carboxylate 
• 873945-20-1 benzyl 4-{4-[1-(3-fluorophenyl)pyrrolidin-3-yloxy]phenyl}-3-hydroxy-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]-oxazin-6-ylmethoxy]piperidine-1-carboxylate 
• 873946-31-7 4-{4-[1-(3-fluoro-phenyl)-pyrrolidin-3-yloxy]-phenyl}-3-methanesulphonyloxy-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]-oxazin-6-ylmethoxy]-piperidine-1-carboxylic acid benzyl ester 
• 873946-54-4 3-[4-{4-[1-(3-fluoro-phenyl)pyrrolidin-3-yloxy]-phenyl}-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-piperidin-3-yloxy]-propionitrile 
• 873945-22-3 benzyl 4-{4-[1-(3-fluorophenyl)pyrrolidin-3-yloxy]phenyl}-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxypiperidine-1-carboxylate 
• 873946-53-3 6-{4-{4-[1-(3-fluoro-phenyl)-pyrrolidin-3-yloxy]-phenyl}-5-[2-(1H-tetrazol-5-yl)-ethoxy]-1-(toluene-4-sulfonyl)-piperidin-3-yloxymethyl}-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine 
• 873945-23-4 benzyl 4-{4-[1-(3-fluorophenyl)pyrrolidin-3-yloxy]phenyl}-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxypiperidine-1-carboxylate 

Relevant articles and documents

Substituted Piperidines as Renin Inhibitors

Compounds of the general formula (I) in which the meanings of the substituents R1, R2, R3, R4, X, Z and n as stated in claim 1 have renin-inhibiting properties and can be used as medicines.

Substituted piperidines as therapeutic compounds

Use of compounds of the general formula (1) and pharmaceutically acceptable salt thereof, in which R1, R2, R3, R4, W, X, Z and n have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibitors.

SUBSTITUTED 4-PHENYLPIPERIDINES

The application relates to substituted 4-phenylpiperidines of the general formula and their salts, preferably their pharmaceutically acceptable salts, in which R2, R3, W and X have the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.