874157-87-6

Basic information

• Product Name: 2-{methoxy-[1-(4-nitro-phenylmethanesulfonylamino)-ethyl]-phosphinoylmethyl}-pentanedioic acid dimethyl ester
• CAS NO: 874157-87-6
• Molecular Weight: 494.46
• Mol File: 874157-87-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{methoxy-[1-(4-nitro-phenylmethanesulfonylamino)-ethyl]-phosphinoylmethyl}-pentanedioic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{methoxy-[1-(4-nitro-phenylmethanesulfonylamino)-ethyl]-phosphinoylmethyl}-pentanedioic acid dimethyl ester(874157-87-6)
• EPA Substance Registry System: 2-{methoxy-[1-(4-nitro-phenylmethanesulfonylamino)-ethyl]-phosphinoylmethyl}-pentanedioic acid dimethyl ester(874157-87-6)

Safety Data

• Hazardous Substances Data: 874157-87-6(Hazardous Substances Data)

Upstream product

• 174280-81-0 methyl <1-<(benzyloxycarbonyl)amino>ethyl>(2,4-dicarbomethoxybutyl)phosphinate 
• 874156-89-5 2-[(1-Amino-ethyl)-methoxy-phosphinoylmethyl]-pentanedioic acid dimethyl ester 
• 4025-75-6 (4-nitrophenyl)methanesulfonyl chloride 

Relevant articles and documents

Design, synthesis and structure-activity relationships of new phosphinate inhibitors of MurD

A series of new phosphinate compounds were designed and synthesized as inhibitors of the d-glutamic acid-adding enzyme (MurD) involved in peptidoglycan biosynthesis. They were tested against the MurD enzyme from Escherichia coli, allowing initial structure-activity relationships to be deduced. Two compounds had IC50 values near 100 μM and constitute a promising starting point for further development.