174280-81-0

Basic information

• Product Name: Pentanedioic acid, 2-[[methoxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]- , dimethyl ester
• CAS NO: 174280-81-0
• Molecular Formula: C19H28NO8P
• Molecular Weight: 429.407
• Mol File: 174280-81-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pentanedioic acid, 2-[[methoxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]- , dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanedioic acid, 2-[[methoxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]- , dimethyl ester(174280-81-0)
• EPA Substance Registry System: Pentanedioic acid, 2-[[methoxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]- , dimethyl ester(174280-81-0)

Safety Data

• Hazardous Substances Data: 174280-81-0(Hazardous Substances Data)

Upstream product

• 5621-44-3 dimethyl 2-methylenepentanedioate 
• 113592-12-4 methyl <1-<(benzyloxycarbonyl)amino>ethyl>phosphinate 
• 108327-37-3 [1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid 

Downstream Products

• 174280-83-2 2-({1-[6-(Diphenoxy-phosphoryloxy)-hexanoylamino]-ethyl}-methoxy-phosphinoylmethyl)-pentanedioic acid dimethyl ester 
• 874161-66-7 2-(Methoxy-{1-[(R)-2-(4-nitro-phenylmethanesulfonylamino)-propionylamino]-ethyl}-phosphinoylmethyl)-pentanedioic acid dimethyl ester 
• 874161-64-5 2-(Methoxy-{1-[(R)-2-(3-nitro-phenylmethanesulfonylamino)-propionylamino]-ethyl}-phosphinoylmethyl)-pentanedioic acid dimethyl ester 
• 874157-77-4 2-{methoxy-[1-(3-trifluoromethyl-phenylmethanesulfonylamino)-ethyl]-phosphinoylmethyl}-pentanedioic acid dimethyl ester 
• 874157-81-0 2-{[1-(2-chloro-4-fluoro-phenylmethanesulfonylamino)-ethyl]-methoxy-phosphinoylmethyl}-pentanedioic acid dimethyl ester 
• 874157-83-2 2-{methoxy-[1-(2-nitro-phenylmethanesulfonylamino)-ethyl]-phosphinoylmethyl}-pentanedioic acid dimethyl ester 
• 874157-87-6 2-{methoxy-[1-(4-nitro-phenylmethanesulfonylamino)-ethyl]-phosphinoylmethyl}-pentanedioic acid dimethyl ester 
• 874161-58-7 2-({1-[(E)-3-(3-Hydroxy-phenyl)-acryloylamino]-ethyl}-methoxy-phosphinoylmethyl)-pentanedioic acid dimethyl ester 
• 874157-71-8 2-{methoxy-[1-(3-nitro-benzenesulfonylamino)-ethyl]-phosphinoylmethyl}-pentanedioic acid dimethyl ester 
• 874161-57-6 2-(Methoxy-{1-[(E)-(3-phenyl-acryloyl)amino]-ethyl}-phosphinoylmethyl)-pentanedioic acid dimethyl ester 

Relevant articles and documents

Design, synthesis and structure-activity relationships of new phosphinate inhibitors of MurD

A series of new phosphinate compounds were designed and synthesized as inhibitors of the d-glutamic acid-adding enzyme (MurD) involved in peptidoglycan biosynthesis. They were tested against the MurD enzyme from Escherichia coli, allowing initial structure-activity relationships to be deduced. Two compounds had IC50 values near 100 μM and constitute a promising starting point for further development.