874161-58-7

Basic information

• Product Name: Pentanedioic acid, 2-[[[1-[[(2E)-3-(3-hydroxyphenyl)-1-oxo-2-propenyl]amino]ethyl]methoxy phosphinyl]methyl]-, dimethyl ester
• CAS NO: 874161-58-7
• Molecular Formula: C20H28NO8P
• Molecular Weight: 441.418
• Mol File: 874161-58-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pentanedioic acid, 2-[[[1-[[(2E)-3-(3-hydroxyphenyl)-1-oxo-2-propenyl]amino]ethyl]methoxy phosphinyl]methyl]-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanedioic acid, 2-[[[1-[[(2E)-3-(3-hydroxyphenyl)-1-oxo-2-propenyl]amino]ethyl]methoxy phosphinyl]methyl]-, dimethyl ester(874161-58-7)
• EPA Substance Registry System: Pentanedioic acid, 2-[[[1-[[(2E)-3-(3-hydroxyphenyl)-1-oxo-2-propenyl]amino]ethyl]methoxy phosphinyl]methyl]-, dimethyl ester(874161-58-7)

Safety Data

• Hazardous Substances Data: 874161-58-7(Hazardous Substances Data)

Upstream product

• 174280-81-0 methyl <1-<(benzyloxycarbonyl)amino>ethyl>(2,4-dicarbomethoxybutyl)phosphinate 
• 14755-02-3 3-hydroxy-trans-cinnamic acid 
• 874156-89-5 2-[(1-Amino-ethyl)-methoxy-phosphinoylmethyl]-pentanedioic acid dimethyl ester 

Relevant articles and documents

Design, synthesis and structure-activity relationships of new phosphinate inhibitors of MurD

A series of new phosphinate compounds were designed and synthesized as inhibitors of the d-glutamic acid-adding enzyme (MurD) involved in peptidoglycan biosynthesis. They were tested against the MurD enzyme from Escherichia coli, allowing initial structure-activity relationships to be deduced. Two compounds had IC50 values near 100 μM and constitute a promising starting point for further development.