874208-93-2 Usage
Description
mPEG5-t-buyl ester is a PEG (polyethylene glycol) linker that features a t-butyl ester group. This t-butyl ester group is designed to be deprotected under acidic conditions, revealing the carboxyl group. The hydrophilic nature of the PEG spacer enhances the solubility of mPEG5-t-buyl ester in aqueous media, making it a versatile component in various applications.
Uses
Used in Pharmaceutical Industry:
mPEG5-t-buyl ester is used as a solubility enhancer for hydrophobic drugs. The hydrophilic PEG spacer increases the solubility of the drug in aqueous media, improving its bioavailability and therapeutic efficacy.
Used in Drug Delivery Systems:
mPEG5-t-buyl ester is used as a functional component in the design of drug delivery systems. The t-butyl protected carboxyl group can be deprotected under acidic conditions, allowing for the controlled release of the drug in specific environments, such as tumor tissues or intracellular compartments.
Used in Bioconjugation:
mPEG5-t-buyl ester is used as a bioconjugation agent to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The deprotection of the t-butyl ester group under acidic conditions enables the formation of stable covalent bonds with target molecules.
Used in Chemical Synthesis:
mPEG5-t-buyl ester is used as a protected intermediate in the synthesis of various chemical compounds. The t-butyl ester group can be selectively deprotected under acidic conditions, allowing for further chemical reactions to be carried out on the exposed carboxyl group.
Check Digit Verification of cas no
The CAS Registry Mumber 874208-93-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,2,0 and 8 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 874208-93:
(8*8)+(7*7)+(6*4)+(5*2)+(4*0)+(3*8)+(2*9)+(1*3)=192
192 % 10 = 2
So 874208-93-2 is a valid CAS Registry Number.
874208-93-2Relevant articles and documents
Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof
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Page/Page column 31, (2008/06/13)
Fatty acid compositions for administration of of pharmaceutical agents, such as proteins and peptides, protein and peptide conjugates, and/or cation-polypeptide conjugate complexes. In particular, the invention provides a solid pharmaceutical composition
