874482-94-7

Basic information

• Product Name: Benzonitrile, 2-chloro-4-(trifluoromethoxy)-
• CAS NO: 874482-94-7
• Molecular Formula: C8H3ClF3NO
• Molecular Weight: 221.566
• Mol File: 874482-94-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 2-chloro-4-(trifluoromethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 2-chloro-4-(trifluoromethoxy)-(874482-94-7)
• EPA Substance Registry System: Benzonitrile, 2-chloro-4-(trifluoromethoxy)-(874482-94-7)

Safety Data

• Hazardous Substances Data: 874482-94-7(Hazardous Substances Data)

Upstream product

• 653578-64-4 2-chloro-4-(trifluoromethoxy)phenyltrifluoromethane sulfonate 
• 557-21-1 dicyanozinc 
• 1006904-72-8 silver(I) trifluoromethoxide 
• 20925-27-3 4-amino-2-chlorobenzonitrile 
• 773837-37-9 sodium cyanide 
• 69695-61-0 2-chloro-4-(trifluoromethoxy)aniline 
• 557-21-1 zinc(II) cyanide 
• 70783-75-4 4-(trifluoromethoxy)-2-chlorophenol 

Downstream Products

• 1079351-20-4 2-chloro-4-trifluoromethoxybenzaldehyde 
• 874571-72-9 1-[2-chloro-4-(trifluoromethoxy)phenyl]methanamine 

Relevant articles and documents

Silver-Mediated Trifluoromethoxylation of (Hetero)aryldiazonium Tetrafluoroborates

Here we report a silver-mediated trifluoromethoxylation of (hetero)aryldiazonium tetrafluoroborates by converting an aromatic amino group into an OCF3 group. This method, which can be considered to be a trifluoromethoxylation variation of the classic Sandmeyer-type reaction, uses readily available aryl and heteroaromatic amines as starting materials and AgOCF3 as trifluoromethoxylating reagents. The broad substrate scope and simple, mild reaction condition made this transformation a valuable method in constructing aryl-OCF3 bonds.

INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS

Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Formula (I). Also provided herein are pharmaceutical compositions, comprising compounds of Formula (I), and methods of using compounds of Formula (I).

BICYCLIC HETEROCYCLIC COMPOUND

In the prevention and/or treatment of a neuropsychiatric disease or a peripheral organ disease and the like, a pharmaceutical which comprises a compound having CRF antagonistic activity as an active ingredient is provided. A compound of a formula (I): wherein R1 represents a C3-10 branched alkyl group which may be substituted; R2 represents a hydrogen atom or a C1-4 alkyl group which may be substituted; R3 represents a C1-4 alkyl group which may be substituted or a halogen atom; R4 represents a C1-4 alkyl group which may be substituted; and ring 1 represents a cyclic group which has planarity and may have a substituent group, a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof, is useful as a medicinal component having CRF antagonistic activity for the prevention and/or treatment of a neuropsychiatric disease, a peripheral organ disease and the like.