874974-85-3

Basic information

• Product Name: Benzonitrile, 3-(difluoromethyl)-5-hydroxy-
• CAS NO: 874974-85-3
• Molecular Formula: C8H5F2NO
• Molecular Weight: 169.131
• Mol File: 874974-85-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 3-(difluoromethyl)-5-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 3-(difluoromethyl)-5-hydroxy-(874974-85-3)
• EPA Substance Registry System: Benzonitrile, 3-(difluoromethyl)-5-hydroxy-(874974-85-3)

Safety Data

• Hazardous Substances Data: 874974-85-3(Hazardous Substances Data)

Upstream product

• 1089730-71-1 3-(difluoromethyl)-5-((4-methoxybenzyl)oxy)benzonitrile 
• 1089730-72-2 3-formyl-5-((4-methoxybenzyl)oxy)benzonitrile 
• 1068604-47-6 3-((4-methoxybenzyl)oxy)-5-vinylbenzonitrile 
• 1213790-87-4 3-chloro-5-((4-methoxybenzyl)oxy)benzonitrile 
• 473923-97-6 3-chloro-5-hydroxybenzonitrile 
• 1007572-09-9 3-difluoromethyl-5-methoxy-benzonitrile 

Downstream Products

• 1068603-76-8 3-difluoromethyl-5-(2,3-difluoro-6-nitro-phenoxy)-benzonitrile 
• 874974-86-4 C₁₈H₁₃F₃N₂O₅ 
• 1338226-04-2 3-(difluoromethyl)-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile 
• 910825-41-1 C₁₅H₇BrF₃NO₂ 

Relevant articles and documents

PYRIMIDONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS

The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).

HETEROCYCLIC ANTIVIRAL COMPOUNDS

The present invention relates to a method of treating an HIV-I infection with a compound according to formula I where R1, R2, R3, R4, R5, are as defined herein.

Non-nucleoside reverse transcriptase inhibitors

The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A1, A2, A3 or A4 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.