875680-89-0

Basic information

• Product Name: Carbamic acid, [(1R)-1-methyl-3-[[(2-nitrophenyl)sulfonyl]amino]propyl]-, 1,1-dimethylethyl ester
• CAS NO: 875680-89-0
• Molecular Formula: C15H23N3O6S
• Molecular Weight: 373.43
• Mol File: 875680-89-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1R)-1-methyl-3-[[(2-nitrophenyl)sulfonyl]amino]propyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R)-1-methyl-3-[[(2-nitrophenyl)sulfonyl]amino]propyl]-, 1,1-dimethylethyl ester(875680-89-0)
• EPA Substance Registry System: Carbamic acid, [(1R)-1-methyl-3-[[(2-nitrophenyl)sulfonyl]amino]propyl]-, 1,1-dimethylethyl ester(875680-89-0)

Safety Data

• Hazardous Substances Data: 875680-89-0(Hazardous Substances Data)

Upstream product

• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 170367-69-8 (3-amino-1(R)-methylpropyl)carbamic acid, 1,1-dimethylethyl ester 
• 170367-68-7 (2-cyano-1(R)-methylethyl)carbamic acid, 1,1-dimethylethyl ester 

Downstream Products

• 875680-93-6 (R)-N¹-phthaloyl-N⁵-(o-nitrophenylsulfonyl)-N⁸-acetyl-1,8-diamino-5-azanonane 
• 932032-31-0 (R)-N¹²-(tert-butyloxycarbonyl)-N⁹-(o-nitrophenylsulfonyl)-1,12-diamino-4,9-diazatridecane 
• 932032-30-9 (R)-N⁵-(o-nitrophenylsulfonyl)-N⁸-(tert-butyloxycarbonyl)-8-amino-5-aza-1-iodononane 
• 875680-91-4 (R)-N¹-phthaloyl-N⁵-(o-nitrophenylsulfonyl)-N⁸-(tert-butyloxycarbonyl)-1,8-diamino-5-azanonane 

Relevant articles and documents

Practical and scalable synthesis of orthogonally protected-2-substituted chiral piperazines

A synthetic route to orthogonally protected, enantiomerically pure 2-substituted piperazines is described. Starting from α-amino acids, within four steps chiral 2-substituted piperazines are obtained. The key transformation involves an aza-Michael additio

α-methyl polyamines: Efficient synthesis and tolerance studies in vivo and in vitro. First evidence for dormant stereospecificity of polyamine oxidase

Efficient syntheses of metabolically stable α-methylspermidine 1, α-methylspermine 2, and bis-α,α-methylated spermine 3 starting from ethyl 3-aminobutyrate are described. The biological tolerance for these compounds was tested in wild-type mice and transgenic mice carrying the metallothionein promoter-driven spermidine/spermine N1- acetyltransferase gene (MT-SSAT). The efficient substitution of natural polyamines by their derivatives was confirmed in vivo with the rats harboring the same MT-SSAT transgene and in vitro with the immortalized fibroblasts derived from these animals. Enantiomers of previously unknown 1-amino-8-acetamido-5-azanonane dihydrochloride 4 were synthesized starting from enantiomerically pure (R)- and (S)-alaninols. The studies with recombinant human polyamine oxidase (PAO) showed that PAO (usually splits achiral substrates) strongly favors the (R)-isomer of 4 that demonstrates for the first time that the enzyme has hidden potency for stereospecificity.