876189-18-3

Basic information

• Product Name: 5-Methoxycarbonyl-2-methylphenylboronic acid
• Synonyms: 5-Methoxycarbonyl-2-methylphenylboronic acid;Methyl 3-borono-4-methylbenzoate
• CAS NO: 876189-18-3
• Molecular Formula: C₉H₁₁BO₄
• Molecular Weight: 193.99224
• Mol File: 876189-18-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 375.353 °C at 760 mmHg
• Flash Point: 180.807 °C
• Appearance: /
• Density: 1.219 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: Room temperature.
• PKA: 7.81±0.58(Predicted)
• CAS DataBase Reference: 5-Methoxycarbonyl-2-methylphenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxycarbonyl-2-methylphenylboronic acid(876189-18-3)
• EPA Substance Registry System: 5-Methoxycarbonyl-2-methylphenylboronic acid(876189-18-3)

Safety Data

• Hazardous Substances Data: 876189-18-3(Hazardous Substances Data)

Usage

General Description

5-Methoxycarbonyl-2-methylphenylboronic acid is a chemical compound that belongs to the class of phenylboronic acids, which are widely used in organic synthesis and medicinal chemistry. It is a boronic acid derivative with a methoxycarbonyl group and a methyl group attached to the phenyl ring. Boronic acids are known for their ability to form stable covalent complexes with diols and other Lewis bases, making them valuable tools in the development of sensors, catalysts, and pharmaceuticals. This particular compound has potential applications in Suzuki-Miyaura cross-coupling reactions, which are important in the synthesis of complex organic molecules. Additionally, its ability to form reversible covalent bonds with biological targets has implications for the development of new drug candidates. Overall, 5-Methoxycarbonyl-2-methylphenylboronic acid has diverse and promising applications in the fields of chemistry and pharmaceuticals.

InChI:InChI=1/C9H11BO4/c1-6-3-4-7(9(11)14-2)5-8(6)10(12)13/h3-5,12-13H,1-2H3

Upstream product

• 90347-66-3 methyl 3-iodo-4-methylbenzoate 
• 67-56-1 methanol 
• 170230-88-3 3-carboxy-6-methylphenylboronic acid 
• 7697-26-9 3-bromo-4-methylbenzoic acid 
• 104901-43-1 methyl 3-bromo-4-methylbenzoate 
• 7664-93-9 sulfuric acid 
• 882679-40-5 methyl 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 

Downstream Products

• 1070292-54-4 4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzoic acid methyl ester 
• 1070292-87-3 3-[2-(4-methoxybenzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-4-methylbenzoic acid methyl ester 
• 1221343-13-0 methyl 3-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-4-methylbenzoate 
• 882679-40-5 methyl 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 1221343-14-1 1-(hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)carboxylic acid 
• 1070292-57-7 3-(2-benzyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-methylbenzoyl chloride 
• 1070292-75-9 N-cyclopropyl-4-methyl-3-(1-oxo-1,2-dihydroisoquinolin-6-yl)benzamide 

Relevant articles and documents

1, 1 '-biphenyl-2, 6-diphenol compound and application thereof

The invention discloses a 1, 1 '-biphenyl-2, 6-diphenol compound and application thereof, and the 1, 1'-biphenyl-2, 6-diphenol compound is a new compound and has good biological activity. Through an in-vitro tumor cell activity experiment method, it is fo

BORON-CONTAINING DIACYLHYDRAZINES

The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

Noncryogenic I/Br-Mg exchange of aromatic halides bearing sensitive functional groups using i-PrMgCl-Bis[2-(N,N-dimethylamino)ethyl] ether complexes

Iodo- and bromoaromatics bearing sensitive carboxylic ester and cyano groups underwent a selective halide-magnesium exchange with isopropylmagnesium chloride at ambient temperature in the presence of bis[2-(N,N-dimethylamino) ethyl] ether to afford the corresponding Grignard reagents. The newly formed reactive Grignard reagents were allowed to react with electrophiles such as trimethylborate to afford arylboronic acids in good to excellent yields.