882679-40-5

Basic information

• Product Name: METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE
• Synonyms: METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE;5-Methoxycarbonyl-2-methylphenylboronic acid pinacol ester;Benzoic acid, 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester;Methyl4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl
• CAS NO: 882679-40-5
• Molecular Formula: C₁₅H₂₁BO₄
• Molecular Weight: 276.14
• Mol File: 882679-40-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 383.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.07±0.1 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• CAS DataBase Reference: METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE(882679-40-5)
• EPA Substance Registry System: METHYL 4-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOATE(882679-40-5)

Safety Data

• Hazardous Substances Data: 882679-40-5(Hazardous Substances Data)

Usage

General Description

Methyl 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate is a chemical compound that belongs to the class of esters. It is typically used as a reagent in organic synthesis, especially in the process of acylation and alkylation reactions. This chemical is often employed as a building block in the development of pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable tool for researchers in the field of medicinal and agricultural chemistry. Additionally, it is known for its stability and compatibility with a variety of solvents and reaction conditions, making it a versatile and useful compound in various chemical applications.

Upstream product

• 1350764-46-3 CF₃C₆H₄SO₂O(C₆H₃(CH₃)COOCH₃) 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 104901-43-1 methyl 3-bromo-4-methylbenzoate 
• 73183-34-3 bis(pinacol)diborane 
• 90347-66-3 methyl 3-iodo-4-methylbenzoate 
• 82998-57-0 3-iodo-4-toluic acid 
• 876189-18-3 [5-(methoxycarbonyl)-2-methylphenyl]boronic acid 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 7697-26-9 3-bromo-4-methylbenzoic acid 
• 170230-88-3 3-carboxy-6-methylphenylboronic acid 
• 99-75-2 4-methyl-benzoic acid methyl ester 

Downstream Products

• 1333264-35-9 (3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylphenyl)methanol 
• 1333264-34-8 1-[4-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperazin-1-yl]ethanone 
• 1333264-78-0 tert-butyl 4-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperazine-1-carboxylate 
• 1333264-79-1 1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-[2-methyl-5-(piperazin-1-ylmethyl)phenyl]-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2-dioxide 
• 1333264-77-9 (2R)-1-[4-(3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzyl)piperazin-1-yl]-2-hydroxypropan-1-one 
• 1333264-27-9 methyl 3-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridin-5-yl}-4-methylbenzoate 
• 1221343-14-1 1-(hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)carboxylic acid 
• 1393479-22-5 methyl 4-methyl-3-(2,2,2-trifluoroethyl)benzoate 
• 1459216-73-9 (R)-methyl 3-(5-amino-6-(1-(4-chlorophenyl)ethylamino)pyrazin-2-yl)-4-methylbenzoate 
• 1533442-82-8 methyl 4-methyl-3-(1H-pyrazol-5-yl)benzoate 

Relevant articles and documents

Catalytic Synthesis of Atropisomeric o-Terphenyls with 1,2-Diaxes via Axial-to-Axial Diastereoinduction

Herein, we report a modular and convergent strategy for the assembly of atropisomeric o-terphenyls with 1,2-diaxes via palladium/chiral norbornene cooperative catalysis and axial-to-axial diastereoinduction. Readily available aryl iodides, 2,6-substituted aryl bromides, and potassium aryl trifluoroborates are used as the building blocks, laying the foundation for diversity-oriented synthesis of these scaffolds (46 examples). Other features include the unique axial-to-axial diastereoinduction mode, construction of two axes in a single operation, and step economy. DFT calculations are performed to rationalize the axial-to-axial diastereoinduction process. Synthetic utilities of this method in preparation of atropisomeric oligophenyls, chiral catalysts, and ligands are demonstrated.

C-H borylation by platinum catalysis

Herein, we describe the platinum-catalyzed borylation of aromatic C-H bonds. N-Heterocyclic carbene-ligated platinum catalysts are found to be efficient catalysts for the borylation of aromatic C(sp2)-H bonds when bis(pinacolato)diboron is used as the boron source. The most remarkable feature of these Pt catalysts is their lack of sensitivity towards the degree of steric hindrance around the C-H bonds undergoing the borylation reaction. These Pt catalysts allow for the synthesis of sterically congested 2,6-disubstituted phenylboronic esters, which are otherwise difficult to synthesize using existing C-H borylation methods. Furthermore, platinum catalysis allows for the site-selective borylation of the C-H bonds ortho to fluorine substituents in fluoroarene systems. Preliminary mechanistic studies and work towards the synthetic application of this platinum catalyzed C-H borylation process are described.

TRICYCLIC COMPOUND AND USE THEREOF

The present invention relates to: a compound selected from the group consisting of a tricyclic compound having the structure of formula I, a pharmaceutically acceptable salt, an isomer, a solvate and a precursor thereof; and a use thereof. The compound effectively controls GPR40, and thus, can be effectively used for the prophylaxis or treatment of diseases associated with GPR40, for example, diabetes and many other diseases.