87637-30-7

Basic information

• Product Name: Benzamide, N-[4-(4-chlorophenyl)-2-thiazolyl]-
• CAS NO: 87637-30-7
• Molecular Formula: C16H11ClN2OS
• Molecular Weight: 314.795
• Mol File: 87637-30-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[4-(4-chlorophenyl)-2-thiazolyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[4-(4-chlorophenyl)-2-thiazolyl]-(87637-30-7)
• EPA Substance Registry System: Benzamide, N-[4-(4-chlorophenyl)-2-thiazolyl]-(87637-30-7)

Safety Data

• Hazardous Substances Data: 87637-30-7(Hazardous Substances Data)

Upstream product

• 2103-99-3 4-(4-chlorophenyl)-2-thiazolamine 
• 98-88-4 benzoyl chloride 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 99-91-2 para-chloroacetophenone 
• 614-23-3 N-benzoylthiourea 

Downstream Products

• 103966-17-2 1-(4-p-chlorophenylthiazol-2-yl)-5-phenyltetrazole 
• 103966-25-2 2-phenyl-5-p-chlorophenylthiazolo<3,2-b>-s-triazole 
• 64343-57-3 N-(4-p-chlorophenylthiazole-2-yl)phenylimidoyl chloride 

Relevant articles and documents

Molecular properties prediction, synthesis, and antimicrobial activity of bis(azolyl)sulfonamidoacetamides

A library of bis(azolyl)sulfonamidoacetamides was prepared by the reaction of azolylsulfonylamines with azolylchloroacetamides in the presence of pyridine/4-(dimethylamino)pyridine (DMAP) under ultrasonication. The reaction proceeded well with DMAP, resulting in a higher yield of the products. The antimicrobial activity of the compounds indicated that N-{5-[N-(2-{[4-(4-chloro-1H-pyrrol-2-yl)-1H-imidazol-2-yl)amino}-2-oxoethyl)sulfamoyl]-4-phenylthiazol-2-yl}benzamide (22a), N-{5-[N-(2-{[4-(4-chloro-1H-pyrrol-2-yl)-1H-imidazol-2-yl]amino}-2-oxoethyl)sulfamoyl]-4-(4-chlorophenyl)thiazol-2-yl}benzamide (22c), and N-{5-[N-(2-{[4-(4-chloro-1H-pyrrol-2-yl)-1H-imidazol-2-yl]amino}-2-oxoethyl)sulfamoyl]-4-(4-chloro-phenyl)-1H-imidazol-2-yl}benzamide (24c) exhibited a low minimal inhibitory concentration (MIC) against Bacillus subtilis, equal to the standard drug, chloramphenicol. Compounds 22c and 24c also showed low MICs against Aspergillus niger, equal to the standard drug, ketoconazole. The molecular properties of the synthesized molecules were studied to identify druglikeness properties of the target compounds. On the basis of molecular properties prediction, 19a, 19b, 20b, 20c, 21a–c, 22b, 22c, and 23a–c can be treated as drug candidates.

Synthesis and antimicrobial activity of bisazolylsulfonyl amines

A variety of bisazolylsulfonyl amines have been prepared from azolylsulfonyl chlorides and azolylsulfonamides and their antimicrobial activity studied. The chloro substituted bisthiazolylsulfonyl amines exhibit pronounced antibacterial activity against B.

PhCOCI-Py/basic alumina as a versatile reagent for benzoylation in solvent-free conditions

A solvent-free procedure using PhCOCl-Py/basic alumina under microwave irradiation has been developed for N-, O- and S-benzoylation.