876761-29-4

Basic information

• Product Name: 4-(2-amino-5-phenoxy-benzylamino)-4,N-dicyclohexyl-N-methyl-butyramide
• Synonyms: 4-(2-amino-5-phenoxy-benzylamino)-4,N-dicyclohexyl-N-methyl-butyramide
• CAS NO: 876761-29-4
• Molecular Weight: 477.69
• Mol File: 876761-29-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-amino-5-phenoxy-benzylamino)-4,N-dicyclohexyl-N-methyl-butyramide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-amino-5-phenoxy-benzylamino)-4,N-dicyclohexyl-N-methyl-butyramide(876761-29-4)
• EPA Substance Registry System: 4-(2-amino-5-phenoxy-benzylamino)-4,N-dicyclohexyl-N-methyl-butyramide(876761-29-4)

Safety Data

• Hazardous Substances Data: 876761-29-4(Hazardous Substances Data)

Upstream product

• 171560-20-6 (2R)-2-(1,1-dimethylethoxycarbonylamino)-2-cyclohexylethanal 
• 100-60-7 N-methylcyclohexylamine 
• 876761-24-9 C₁₇H₂₉NO₄ 
• 876761-25-0 4-tert-butoxycarbonylamino-4-cyclohexyl-butyric acid 
• 548798-25-0 2-nitro-5-phenoxybenzaldehyde 

Downstream Products

• 877032-57-0 4-(2-amino-6-phenoxy-4H-quinazolin-3-yl)-4-(S)-,N-dicyclohexyl-N-methyl-butyramide 
• 876761-22-7 4-(2-amino-6-phenoxy-4H-quinazolin-3-yl)-4-(S)-,N-dicyclohexyl-N-methyl-butyramide hydrobromide 
• 876761-22-7 C₃₁H₄₂N₄O₂*1.3HBr 

Relevant articles and documents

Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors

Structure-based design, synthesis, and biological evaluation of a series of dihydroquinazoline-derived β-secretase inhibitors incorporating thiazole and pyrazole-derived P2-ligands are described. We have identified inhibitor 4f which has shown potent enzyme inhibitory (Ki = 13 nM) and cellular (IC50 = 21 nM in neuroblastoma cells) assays. A model of 4f was created based upon the X-ray structure of 3a-bound β-secretase. The model suggested possible interactions in the active site.