87698-82-6

Basic information

• Product Name: 2-BROMOPHENYLMORPHOLINE
• Synonyms: 2-BROMOPHENYLMORPHOLINE;1-Bromo-2-morpholinobenzene;4-(2-Bromophenyl)morpholine;N-(2-BroMophenyl)Morpholine;N-(2-BroMophenyl)Morpholin
• CAS NO: 87698-82-6
• Molecular Formula: C₁₀H₁₂BrNO
• Molecular Weight: 242.11
• Mol File: 87698-82-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 324.8±37.0 °C(Predicted)
• Appearance: /
• Density: 1.433±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: 4.47±0.40(Predicted)
• CAS DataBase Reference: 2-BROMOPHENYLMORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMOPHENYLMORPHOLINE(87698-82-6)
• EPA Substance Registry System: 2-BROMOPHENYLMORPHOLINE(87698-82-6)

Safety Data

• Hazardous Substances Data: 87698-82-6(Hazardous Substances Data)

Usage

General Description

2-Bromophenylmorpholine, also known as 2-Bromo-4-morpholinophenyl, is a chemical compound that is commonly used as an intermediate in the synthesis of pharmaceuticals, dyes, and pesticides. It is a white to off-white crystalline powder with a molecular formula of C10H11BrNO and a molecular weight of 244.1 g/mol. 2-Bromophenylmorpholine is known for its ability to act as a nucleophilic catalyst in various organic reactions, and it is also used as a building block for the synthesis of other compounds. The compound is considered to be moderately toxic and may cause irritation to the skin, eyes, and respiratory system upon exposure. Additionally, it is important to handle 2-Bromophenylmorpholine with care and follow proper safety precautions when working with it in a laboratory or industrial setting.

Upstream product

• 5414-19-7 1,1'-oxybis(2-bromo-ethane) 
• 615-36-1 2-bromoaniline 
• 110-91-8 morpholine 
• 583-55-1 1-Bromo-2-iodobenzene 
• 95-56-7 2-hydroxybromobenzene 
• 583-53-9 2,3-dibromobenzene 
• 92-53-5 4-Phenylmorpholine 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 1229227-01-3 C₁₈H₁₂B₃Br₃O₃ 
• 98022-77-6 N-bromomorpholine 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 87698-84-8 Dimethyl (Z)-2-<2-(4-Morpholinyl)phenyl>butenedioate 
• 1237588-12-3 N-(2-(di(1-adamantyl)phosphino)phenyl)morpholine 
• 1237588-14-5 C₂₂H₃₄NOP 
• 1284216-75-6 4-(2-(diphenylphosphino)phenyl)morpholine 
• 1350654-33-9 tris(2-morpholinophenyl)phosphine 
• 1350654-32-8 4,4'-((phenylphosphinediyl)bis(2,1-phenylene))dimorpholine 
• 1355686-73-5 C₂₅H₂₇N₃O₅S 
• 204078-32-0 2-(4-morpholino)benzonitrile 
• 1447992-77-9 C₂₅H₃₄N₃O⁽¹⁺⁾*Cl^(1-) 
• 1447992-85-9 C₄₄H₅₄N₆O₂ 
• 1447992-79-1 C₂₅H₃₄N₃O⁽¹⁺⁾*BF₄^(1-) 
• 1447992-80-4 [1-mesityl-3-{2-(4-morpholinyl)phenyl}imidazolidin-1-ylium] chloride 
• 1447992-82-6 [1-mesityl-3-{2-(4-morpholinyl)phenyl}imidazolidin-1-ylium] tetrafluoroborate 
• 1447992-83-7 C₂₅H₃₃N₃O 

Relevant articles and documents

NOVEL MODULATORS OF THE SIGMA-2 RECEPTOR AND THEIR METHOD OF USE

Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma- 2 receptor activity.

Synthesis of ortho -haloaminoarenes by aryne insertion of nitrogen-halide Bonds

A rapid and general access to ortho-haloaminoarenes has been developed by aryne insertion into N-chloramine, N-bromoamine, and N-iodoamine bonds via two complementary protocols harnessing fluoride-promoted 1,2-elimination of ortho-trimethylsilyl aryltriflates. Typically, electron-deficient N-chloramines effectively react with aryne intermediates generated at elevated temperature with CsF, while less stable N-haloamines are found more efficient under milder, TBAF-mediated aryne formation at room temperature. Both protocols demonstrate a good level of regioselectivity and functional group tolerance. Efforts to elucidate the mechanism of N-X insertion are also discussed. The practical value of this transformation is highlighted by rapid synthesis of novel analogues of the antipsychotic cariprazine.

Transition-metal-free electrophilic amination of arylboroxines

A transition-metal-free strategy to construct C(sp2)-N bonds using arylboroxines and O-benzoyl hydroxylamines as coupling partners has been developed. This transformation provides a useful method to access various aromatic amines.