204078-32-0

Basic information

• Product Name: 2-MORPHOLINOBENZONITRILE
• Synonyms: 2-MORPHOLINOBENZONITRILE;2-(MORPHOLIN-4-YL)BENZONITRILE;4-(2-Cyanophenyl)morpholine
• CAS NO: 204078-32-0
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.22578
• Mol File: 204078-32-0.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 357.4°C at 760 mmHg
• Flash Point: 169.9°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 2.74E-05mmHg at 25°C
• Refractive Index: 1.583
• PKA: 3.13±0.40(Predicted)
• CAS DataBase Reference: 2-MORPHOLINOBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-MORPHOLINOBENZONITRILE(204078-32-0)
• EPA Substance Registry System: 2-MORPHOLINOBENZONITRILE(204078-32-0)

Safety Data

• Statements: 20/22
• Safety Statements: 36/37
• Hazardous Substances Data: 204078-32-0(Hazardous Substances Data)

Usage

Chemical Properties

White crystal

InChI:InChI=1/C11H12N2O/c12-9-10-3-1-2-4-11(10)13-5-7-14-8-6-13/h1-4H,5-8H2

Upstream product

• 110-91-8 morpholine 
• 394-47-8 2-fluorobenzonitrile 
• 873-32-5 2-Chlorobenzonitrile 
• 2042-37-7 o-cyanobromobenzene 
• 87698-82-6 4-(2-bromophenyl)morpholine 

Downstream Products

• 204078-48-8 1-[2-(morpholin-4-yl)phenyl]methanamine 
• 67829-50-9 2-morpholinobenzamide 

Relevant articles and documents

Aryl-Diadamantyl Phosphine Ligands in Palladium-Catalyzed Cross-Coupling Reactions: Synthesis, Structural Analysis, and Application

Synthesis, temperature-dependent NMR structure investigation and utilization of a new, stable and easily accessible aryl-diadamantylphosphine ligand family is reported. The bulky and electron-rich phosphorus center of the ligand enhances the catalytic activity of palladium in cross-coupling reactions of sterically demanding ortho-substituted aryl halides. In our study, we demonstrated the synthetic applicability of the new phosphine ligands in Buchwald-Hartwig and tosyl hydrazone coupling reactions.

SNAr reaction in aqueous medium in the presence of mixed organic and inorganic bases

N-Arylation of amines with fluorobenzonitriles in aqueous medium is described. A mixture of N,N-diisopropylethyl amine and Na2CO3 (1:1) is found to achieve maximum conversion by refluxing for 3 hours in water. The product can be easily isolated by solvent extraction.

Insertion of arynes into N-halo bonds: A direct approach to O -haloaminoarenes

A new approach to access o-haloaminoarenes has been achieved by insertion of arynes into a nitrogen-halide bond (N-X). This transition-metal-free transformation displays a broad substrate scope of arynes, good compatibility with functional groups, and high regioselectivity. Representative transformations of the o-haloaminoarenes are described to highlight their utility for rapid access to diversely functionalized aminoarene derivatives.