87857-41-8

Basic information

• Product Name: (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine
• Synonyms: 1-naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-, (1S,4S)-; 1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-, (1S-cis)-
• CAS NO: 87857-41-8
• Molecular Formula: C₁₆H₁₅Cl₂N
• Molecular Weight: 292.203
• Mol File: 87857-41-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 409.6°C at 760 mmHg
• Flash Point: 201.5°C
• Density: 1.259g/cm³
• Vapor Pressure: 6.41E-07mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine(87857-41-8)
• EPA Substance Registry System: (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine(87857-41-8)

Safety Data

• Hazardous Substances Data: 87857-41-8(Hazardous Substances Data)

Upstream product

• 195388-56-8 (1S,4S)-1-azido-4-(3,4-dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalene 
• 267884-82-2 (1S,4S)-N,N-(dibenzyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine 
• 174023-92-8 D-dibenzylaminophenylglycinal 
• 193476-02-7 (+)-(2R)-2-[bis(phenylmethyl)amino]-2-phenylethanol 
• 267884-81-1 (4S)-N,N-(dibenzyl)-4-amino-4-phenyl-1-butanol 
• 267884-80-0 (4S)-methyl-N,N-(dibenzyl)-4-amino-4-phenylbutanoate 
• 267884-79-7 (4S)-ethyl-4-N,N-(dibenzyl)-4-amino-4-phenyl-(E)-2-butenoate 
• 267884-77-5 (1S,R,4S)-N,N-(dibenzyl)-4-amino-1-(3,4-dichlorophenyl)-4-phenyl-1-butanol 
• 123849-23-0 (R)-(+)-1-hydroxy-1,2-dihydronaphthalene 
• 195388-55-7 (+)-(1R)-4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-ol 
• 195388-52-4 (R)-1-tert-butyldiphenylsiloxy-1,2-dihydro-naphthalene 
• 195388-53-5 (R)-4-bromo-1-tert-butyldiphenylsiloxy-1,2-dihydro-naphthalene 
• 1026451-65-9 tert-Butyl-((R)-3,4-dibromo-1,2,3,4-tetrahydro-naphthalen-1-yloxy)-diphenyl-silane 
• 195388-54-6 (R)-4-tert-butyl(4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yloxy)diphenylsilane 

Downstream Products

• 79617-96-2 Sertraline 
• 267884-84-4 cis-(1S,4S)-N-(tert-butoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine 
• 267884-85-5 cis-(1S,4S)-N-(tert-butoxycarbonyl)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine 

Relevant articles and documents

An expedient total synthesis of cis-(+)-sertraline from D-phenylglycine

An efficient and practical total synthesis of cis-(+)-Sertraline is developed involving intramolecular Friedel-Crafts cyclization of an appropriately tailored D-phenylglycine. (C) 2000 Elsevier Science Ltd.

General strategy toward the tetrahydronaphthalene skeleton. An expedient total synthesis of sertraline

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