87955-28-0Relevant articles and documents
A Concise Stereoselective Synthesis of (R)-2-Benzylmorpholine and ML398 from (R)-(?)-2-Phenylglycinol
Torres, Saúl,Velasco, Manuel,Gallegos-Rojas, José ángel,Bernès, Sylvain,Orea, María L.,Terán, Joel L.,Huelgas, Gabriela,Gómez-Calvario, Víctor,Juárez, Jorge R.
, p. 2677 - 2682 (2019/08/21)
We describe here an efficient stereoselective method for the preparation of (R)-2-benzylmorpholine and ML398. The present method features a high diastereocontrol using an endocyclic oxidation of phenylglycinol-derived morpholine and a stereoselective alky
COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR
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Page/Page column 49-50, (2008/06/13)
Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) wherein, R1, R2, A, Y, X, Ar1 and Ar2 have the meanings given in the specification, and the preparation and use thereof. The compounds are valuable CB2 receptor modulators.
Synthesis and resolution of the novel appetite suppressant 2-benzylmorpholine, a nonstimulant isomer of phenmetrazine
Brown,Forster,Foubister,Stribling
, p. 797 - 799 (2007/10/02)
The synthesis of 2-benzylmorpholine from allylbenzene together with its resolution into its (+)- and (-)-enantiomers is reported. Oral dosing of the racemate to dogs caused appetite suppression with an ED50 of 3 and 5.5 mg kg-1 at 1 and 2 h, re
