88058-45-1Relevant articles and documents
Enantioselective Ruthenium-Catalyzed Benzocyclobutenone-Ketol Cycloaddition: Merging C-C Bond Activation and Transfer Hydrogenative Coupling for Type II Polyketide Construction
Ambler, Brett R.,Turnbull, Ben W. H.,Suravarapu, Sankar Rao,Uteuliyev, Maulen M.,Huynh, Nancy O.,Krische, Michael J.
supporting information, p. 9091 - 9094 (2018/08/03)
The first enantioselective intermolecular metal-catalyzed cycloadditions of benzocyclobutenones via C-C bond oxidative addition are described. In the presence of a ruthenium(0) complex modified by (R)-DM-SEGPHOS, tetralone-derived ketols and benzocyclobutenones combine to form cycloadducts with complete regio- and diastereoselectivity and high enantioselectivity. Using this method, the "bay region" substructure of the angucycline natural product arenimycin was prepared.