881-51-6

Basic information

• Product Name: N-(4-Chloro-2-nitrophenyl)acetamide
• Synonyms: Acetamide,N-(4-chloro-2-nitrophenyl)-;2-Nitro-4-Chloroacetanilide;N-(4-Chloro-2-nitrophenyl)acetamide;N-(2-Nitro-4-chlorophenyl)acetamide;AcetaMide, N-(4-chloro-2-nitrophenyl)- (9CI)
• CAS NO: 881-51-6
• Molecular Formula: C₈H₇ClN₂O₃
• Molecular Weight: 214.61
• Mol File: 881-51-6.mol
• Article Data: 18

Chemical Properties

• Melting Point: 101 °C
• Boiling Point: 399.2 °C at 760 mmHg
• Flash Point: 195.2 °C
• Appearance: /
• Density: 1.466 g/cm³
• Vapor Pressure: 1.39E-06mmHg at 25°C
• Refractive Index: 1.628
• PKA: 12.96±0.70(Predicted)
• CAS DataBase Reference: N-(4-Chloro-2-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Chloro-2-nitrophenyl)acetamide(881-51-6)
• EPA Substance Registry System: N-(4-Chloro-2-nitrophenyl)acetamide(881-51-6)

Safety Data

• Hazardous Substances Data: 881-51-6(Hazardous Substances Data)

Usage

Uses

N-(4-Chloro-2-nitrophenyl)acetamide can be used to synthesize many quinoxaline derivatives.

InChI:InChI=1/C8H7ClN2O3/c1-5(12)10-7-3-2-6(9)4-8(7)11(13)14/h2-4H,1H3,(H,10,12)

Upstream product

• 71331-67-4 4-chloroanilinium nitrate 
• 108-24-7 acetic anhydride 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 89-63-4 4-Chloro-2-nitroaniline 
• 106-47-8 4-chloro-aniline 
• 552-32-9 o-nitroacetanilide 
• 2754-27-0 trimethylsilyl acetate 
• 7697-37-2 nitric acid 
• 88-74-4 2-nitro-aniline 
• 123-54-6 acetylacetone 

Downstream Products

• 51223-59-7 N-(2-amino-4-chlorophenyl)acetamide 
• 89-63-4 4-Chloro-2-nitroaniline 
• 68527-66-2 6-chloro-8-nitroquinoline 
• 2818-69-1 6-chloro-2-methyl-1H-benzo[d]imidazole 
• 17348-69-5 5-chlorobenzofurazan-1-oxide 
• 89284-67-3 1-azido-4-methyl-2-nitrobenzene 
• 25369-78-2 5-chloro-1,3-dihydro-2H-benzo[d]imidazole-2-thione 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 91067-30-0 5-chloro-1,3-diacetylbenzimidazoline-2-thione 
• 91067-21-9 5-Chloro-1,3-bis-phenylaminomethyl-1,3-dihydro-benzoimidazole-2-thione 
• 86569-36-0 N,N'-diacetyl 4-chloro-1,2-phenylenediamine 
• 2818-69-1 5-chloro-2-methyl-1H-benzimidazole 
• 86569-37-1 N-acetyl-N'-propionyl-4-chloro-1,2-phenylenediamine 
• 86569-38-2 N-acetyl-N'-butyryl-4-chloro-1,2-phenylenediamine 

Relevant articles and documents

Method for synthesizing nitro (hetero) aromatic hydrocarbon

The invention discloses a method for synthesizing nitro (hetero) aromatic hydrocarbon, and belongs to the field of organic synthesis. According to the method, simple (hetero) aromatic hydrocarbon is taken as an initial raw material and is stirred and reacted in an organic solvent at 40-100 DEG C under the action of a nitration reagent, a lewis acid catalyst and protective gas, and nitro (hetero) aromatic hydrocarbon can be obtained. The method provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, simple preparation process, good chemical selectivity, wide substrate application range, easy amplification and the like, has great application potential, and lays a good foundation for industrial production.

Transition-metal-free mono- or dinitration of protected anilines

An amide-assisted arene nitration is presented, and both mono- and dinitration of protected anilines could be effected by using NaNO2 and NaNO3 as the mono- and bisnitrating agents, respectively. This divergent synthesis is transition-metal- and acid-free, and features a broad substrate scope, low cost, and ortho–para selectivity.

Regioselective nitration of anilines with Fe(NO3)3·9H2O as a promoter and a nitro source

An efficient Fe(NO3)3·9H2O promoted ortho-nitration reaction of aniline derivatives has been developed. This reaction may go through a nitrogen dioxide radical (NO2) intermediate, which is generated by the thermal decomposition of iron(iii) nitrate. The practicality of the present method using nontoxic and inexpensive iron reagents has been shown by the broad substrate scope and applications.