88129-74-2

Basic information

• Product Name: (R)-(-)-2-phenylbutyric acid ethyl ester
• Synonyms: (R)-(-)-2-phenylbutyric acid ethyl ester
• CAS NO: 88129-74-2
• Molecular Weight: 192.258
• Mol File: 88129-74-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (R)-(-)-2-phenylbutyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-2-phenylbutyric acid ethyl ester(88129-74-2)
• EPA Substance Registry System: (R)-(-)-2-phenylbutyric acid ethyl ester(88129-74-2)

Safety Data

• Hazardous Substances Data: 88129-74-2(Hazardous Substances Data)

Upstream product

• 938-79-4 (2R)-2-phenylbutanoic acid 
• 75-03-6 ethyl iodide 
• 119-43-7 ethyl 2-phenylbutanoate 
• 769-68-6 2-phenylbutanenitrile 
• 64-17-5 ethanol 
• 74042-63-0 (R)-(-)-2-phenylbutyramide 
• 60577-21-1 ethyl α-bromo-α-phenylbutyrate 

Downstream Products

• 16460-75-6 (R)-2-phenyl-butan-1-ol 
• 88129-72-0 (α-phenylpropyl)-(tetramethyl-2,3,4,5)cyclopentadiene 

Relevant articles and documents

Modeling and optimization of lipase-catalyzed hydrolysis for production of (S)-2-phenylbutyric acid enhanced by hydroxyethyl-β-cyclodextrin

An efficient reactive system was established to produce (S)-2-phenylbutyric acid (2-PBA) through the enzymatic enantioselective hydrolysis of 2-phenylbutyrate ester (2-PBAE) in aqueous medium. Lipase CALA from Canadian antarctica and hexyl 2-phenylbutyrate (2-PBAHE) were identified upon screening as the best enzyme and substrate, respectively. Adding hydroxyethyl-β-cyclodextrin (HE-β-CD) to improve the solubility of the substrate resulted in a 1.5 times increase in substrate conversion while retaining a high enantioselectivity compared with that when HE-β-CD was not added. The effects of lipase concentration, substrate concentration and HE-β-CD concentration, temperature, pH, and reaction time on enantiomeric excess and conversion rate were investigated, and the optimal conditions were identified using response surface methodology (RSM). Under the optimal conditions, namely 50 mg/mL lipase CALA, 30 mmol/L substrate, 60 mmol/L HE-β-CD, pH of 6.5, temperature of 83 °C and reaction time of 18 h, the enantiomeric excess and overall conversion rate were 96.05% and 27.28%, respectively. This work provides an efficient alternative method for improving the conversion of aromatic ester substrates by including β-cyclodextrin in an aqueous hydrolysis reaction system.

CHIRAL ORGANOSILICON HYDRIDES

The invention provides a method for enantioselectively reducing a prochiral carbon centred radical having one or more electron donor groups attached directly to the central prochiral carbon atom of the radical, and/or attached to a carbon atom within 1 to 4 atoms of the central prochiral carbon atom, comprising treating said radical with an activated chiral non-racemic organosilicon hydride in the presence of a Lewis acid. The invention also provides a novel class of activated chiral non-racemic organosilicon hydrides.

Enantioselective hydrolysis of various racemic α-substituted arylacetonitriles using Rhodococcus sp. CGMCC 0497

The enantioselective hydrolysis of 17 racemic α-substituted arylacetonitriles by Rhodococcus sp. CGMCC 0497 is described. The corresponding (R)-amides and (S)-acids were obtained with excellent enantiomeric excess in most cases. The effect of steric and electronic factors on the outcome of the reactions are discussed here. The results prove that nitrile-converting enzymes are efficient tools for the synthesis of sterically unencumbered chiral α-arylpropionic acids and amides.