883223-08-3

Basic information

• Product Name: (S)-methyl 3-methyl-2-((4-(4,4,5,5-tetramethyl-2,3,2-dioxaborolan-2-yl)benzyl)amino)butanoate
• Synonyms: (S)-methyl 3-methyl-2-((4-(4,4,5,5-tetramethyl-2,3,2-dioxaborolan-2-yl)benzyl)amino)butanoate
• CAS NO: 883223-08-3
• Molecular Weight: 347.262
• Mol File: 883223-08-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-methyl 3-methyl-2-((4-(4,4,5,5-tetramethyl-2,3,2-dioxaborolan-2-yl)benzyl)amino)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-methyl 3-methyl-2-((4-(4,4,5,5-tetramethyl-2,3,2-dioxaborolan-2-yl)benzyl)amino)butanoate(883223-08-3)
• EPA Substance Registry System: (S)-methyl 3-methyl-2-((4-(4,4,5,5-tetramethyl-2,3,2-dioxaborolan-2-yl)benzyl)amino)butanoate(883223-08-3)

Safety Data

• Hazardous Substances Data: 883223-08-3(Hazardous Substances Data)

Upstream product

• 4070-48-8 L-Valine methyl ester 
• 138500-85-3 4-bromomethylphenylboronic acid pinacol ester 
• 195062-57-8 p-tolylboronic pinacol ester 
• 6306-52-1 L-valine methylester hydrochloride 
• 5084-80-0 tri(4-tolyl)boroxine 
• 76-09-5 2,3-dimethyl-2,3-butane diol 

Downstream Products

• 137863-90-2 methyl 2-(N-((2'-cyanobiphenyl-4-yl)methyl)pentanamido)-3-methylbutanoate 
• 137862-53-4 N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine 
• 883223-10-7 N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester 
• 137863-17-3 methyl N-((2’-(1H-tetrazol-5-yl)-[1,1’-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valinate 
• 883223-09-4 N-pentanoyl-N-[4-(4′,4′,5′,5′-tetramethyl-1′,3′,2′-dioxaborolan-2'-yl)benzyl]-L-valinemethyl ester 

Relevant articles and documents

BIARYLMETHYL HETEROCYCLES

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF AN ANGIOTENSIN II RECEPTOR ANTAGONIST

It comprises new substituted 4-valinylmethylphenyl boronic acids and their derivatives and also its preparation process. It also comprises a preparation process of Valsartan from such intermediates. The process comprises the reaction of the new 4-valinylmethylphenyl boronic compounds with a (halophenyl)tetrazole compound which proceeds with high yields. The process is particularly advantageous in its practical industrial realization because it avoids the use of azide derivatives and also the use of expensive biphenyl intermediates.