883223-10-7

Basic information

• Product Name: N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester
• Synonyms: N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester
• CAS NO: 883223-10-7
• Molecular Weight: 691.873
• Mol File: 883223-10-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester(883223-10-7)
• EPA Substance Registry System: N-pentanoyl-N-{[2'-(2N-trityl-tetrazole-5-yl)(1,1'-biphenyl)-4-yl]methyl}-L-valine methyl ester(883223-10-7)

Safety Data

• Hazardous Substances Data: 883223-10-7(Hazardous Substances Data)

Upstream product

• 852160-37-3 N-[[2'-(2N-trityl-tetrazole-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine methyl-ester hydrobromide 
• 638-29-9 n-valeryl chloride 
• 883223-08-3 (S)-methyl 3-methyl-2-((4-(4,4,5,5-tetramethyl-2,3,2-dioxaborolan-2-yl)benzyl)amino)butanoate 
• 138500-85-3 4-bromomethylphenylboronic acid pinacol ester 
• 195062-57-8 p-tolylboronic pinacol ester 
• 73096-42-1 5-(2-bromophenyl)-2H-tetrazole 
• 5084-80-0 tri(4-tolyl)boroxine 
• 2042-37-7 o-cyanobromobenzene 

Downstream Products

• 137863-17-3 N-pentanoyl-N-[[2'-(1H-tetrazole-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine methyl-ester 
• 137862-53-4 N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine 
• 137863-17-3 methyl N-((2’-(1H-tetrazol-5-yl)-[1,1’-biphenyl]-4-yl)methyl)-N-pentanoyl-L-valinate 

Relevant articles and documents

Efficient synthesis of valsartan, a nonpeptide angiotensin II receptor antagonist

A highly efficient and convergent approach to the synthesis of the angiotensin II receptor antagonist valsartan (1), one of the most important agents used in antihypertensive therapy today, is described. Directed ortho-metalation of 4-bromotoluene provides the key boronic acid intermediate 11 which was subjected to palladium-catalyzed Suzuki coupling. This method overcomes many of the drawbacks associated with the previously reported syntheses. The saponification of the methyl ester in valsartan was realized in a convenient and economical manner, which is more suitable for industrial production. Georg Thieme Verlag Stuttgart.