884512-19-0

Basic information

• Product Name: (3R)-1-(tert-butoxycarbonyl)-3-(2-phenoxybenzoyl)piperidine
• Synonyms: (3R)-1-(tert-butoxycarbonyl)-3-(2-phenoxybenzoyl)piperidine
• CAS NO: 884512-19-0
• Molecular Weight: 381.472
• Mol File: 884512-19-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (3R)-1-(tert-butoxycarbonyl)-3-(2-phenoxybenzoyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-1-(tert-butoxycarbonyl)-3-(2-phenoxybenzoyl)piperidine(884512-19-0)
• EPA Substance Registry System: (3R)-1-(tert-butoxycarbonyl)-3-(2-phenoxybenzoyl)piperidine(884512-19-0)

Safety Data

• Hazardous Substances Data: 884512-19-0(Hazardous Substances Data)

Upstream product

• 884510-86-5 (R)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 
• 13107-20-5 (2-phenoxyphenyl)lithium 
• 101-84-8 diphenylether 
• 163438-09-3 (R)-1-Boc-nipecotic acid 

Downstream Products

• 1071018-45-5 (3R)-tert-butyl 3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidine-1-carboxylate 
• 952709-03-4 ((1R,3S)-3-(t-butoxycarbonylamino)cyclopentyl)((R)-3-((S)-1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidin-1-yl)methanone 
• 1331756-03-6 C₂₉H₄₀N₂O₄ 
• 1071018-55-7 ((1R,3S)-3-(tert-butoxycarbonylamino)cyclopentyl)((3R)-3-(1-hydroxy-5-methoxy-1-(2-phenoxyphenyl)pentyl)piperidin-1-yl)methanone 
• 1071017-32-7 1-((3R)-1-{[(1R,3S)-3-aminocyclopentyl]carbonyl}-3-piperidinyl)-5-(methyloxy)-1[2-(phenyloxy)phenyl]-1-pentanol 
• 884514-26-5 5-methoxy-1-(2-phenoxyphenyl)-1-((R)-piperidin-3-yl)pentan-1-ol 

Relevant articles and documents

Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket

Structure-based design led to the discovery of a novel class of renin inhibitors in which an unprecedented phenyl ring filling the S1 site is attached to the phenyl ring filling the S3 pocket. Optimization for several parameters including potency in the p

RENIN INHIBITORS

Disclosed are compounds of Formula I, wherein the R, R1, R2, R3, X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration

PIPERIDINE AND MORPHOLINE RENIN INHIBITORS

Described are compounds which are orally active and bind to renin to inhibit its activity. They are useful in the treatment or amelioration of diseases associated with renin activity. Also described are methods of use of these compounds for treating or ameliorating a renin mediated disorder in a subject.