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885951-77-9

885951-77-9

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  • 1-(9H-fluoren-9-ylmethoxycarbonylamino)cyclobutane-1-carboxylic acid;Fmoc-1-amino-1-cyclobutanecarboxylic acid;Fmoc-AC4C-OH;Fmoc-cyclovaline;1-(Fmoc-amino)cyclobutanecarboxylic acid;

    Cas No: 885951-77-9

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885951-77-9 Usage

Chemical Properties

White crystalline

Check Digit Verification of cas no

The CAS Registry Mumber 885951-77-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,9,5 and 1 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 885951-77:
(8*8)+(7*8)+(6*5)+(5*9)+(4*5)+(3*1)+(2*7)+(1*7)=239
239 % 10 = 9
So 885951-77-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H19NO4/c22-18(23)20(10-5-11-20)21-19(24)25-12-17-15-8-3-1-6-13(15)14-7-2-4-9-16(14)17/h1-4,6-9,17H,5,10-12H2,(H,21,24)(H,22,23)

885951-77-9 Well-known Company Product Price

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  • Aldrich

  • (39978)  1-(Fmoc-amino)cyclobutanecarboxylicacid  ≥95.0% (HPLC)

  • 885951-77-9

  • 39978-500MG-F

  • 4,815.72CNY

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885951-77-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(9H-fluoren-9-ylmethoxycarbonylamino)cyclobutane-1-carboxylic acid

1.2 Other means of identification

Product number -
Other names Fmoc-1-amino-1-cyclobutanecarboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

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More Details:885951-77-9 SDS

885951-77-9Downstream Products

885951-77-9Relevant articles and documents

Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins

Nicolaou,Yin, Jun,Mandal, Debashis,Erande, Rohan D.,Klahn, Philipp,Jin, Michael,Aujay, Monette,Sandoval, Joseph,Gavrilyuk, Julia,Vourloumis, Dionisios

, p. 1698 - 1708 (2016)

A streamlined total synthesis of N14-desacetoxytubulysin H (Tb1) based on a C-H activation strategy and a short total synthesis of pretubulysin D (PTb-D43) are described. Applications of the developed synthetic strategies and technologies to the synthesis of a series of tubulysin analogues (Tb2-Tb41 and PTb-D42) are also reported. Biological evaluation of the synthesized compounds against an array of cancer cells revealed a number of novel analogues (e.g., Tb14), some with exceptional potencies against certain cell lines [e.g., Tb32 with IC50 = 12 pM against MES SA (uterine sarcoma) cell line and 2 pM against HEK 293T (human embryonic kidney) cell line], and a set of valuable structure-activity relationships. The highly potent cytotoxic compounds discovered in this study are highly desirable as payloads for antibody-drug conjugates and other drug delivery systems for personalized targeted cancer chemotherapies.

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