887150-20-1

Basic information

• Product Name: tert–butyl (2-(((perfluorophenyl)methyl)amino)ethyl)carbamate
• Synonyms: tert–butyl (2-(((perfluorophenyl)methyl)amino)ethyl)carbamate
• CAS NO: 887150-20-1
• Molecular Weight: 340.293
• Mol File: 887150-20-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert–butyl (2-(((perfluorophenyl)methyl)amino)ethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert–butyl (2-(((perfluorophenyl)methyl)amino)ethyl)carbamate(887150-20-1)
• EPA Substance Registry System: tert–butyl (2-(((perfluorophenyl)methyl)amino)ethyl)carbamate(887150-20-1)

Safety Data

• Hazardous Substances Data: 887150-20-1(Hazardous Substances Data)

Upstream product

• 57260-73-8 N-BOC-1,2-diaminoethane 
• 1765-40-8 (bromomethyl)pentafluorobenzene 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 887150-32-5 ((4-Azido-2,3,5,6-tetrafluoro-benzyl)-{2-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethyl}-amino)-acetic acid methyl ester 
• 887150-35-8 ((4-Azido-2,3,5,6-tetrafluoro-benzyl)-{2-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethyl}-amino)-acetic acid 
• 887150-29-0 ({2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethyl}-pentafluorophenylmethyl-amino)-acetic acid methyl ester 
• 887150-26-7 5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid [2-(pentafluorophenylmethyl-amino)-ethyl]-amide 
• 887150-23-4 N¹-pentafluorophenylmethyl-ethane-1,2-diamine 

Relevant articles and documents

Structurally Diverse Histone Deacetylase Photoreactive Probes: Design, Synthesis, and Photolabeling Studies in Live Cells and Tissue

Histone deacetylase (HDAC) activity is modulated in vivo by post-translational modifications and formation of multiprotein complexes. Novel chemical tools to study how these factors affect engagement of HDAC isoforms by HDAC inhibitors (HDACi) in cells and tissues are needed. In this study, a synthetic strategy to access chemically diverse photoreactive probes (PRPs) was developed and used to prepare seven novel HDAC PRPs 9–15. The class I HDAC isoform engagement by PRPs was determined in biochemical assays and photolabeling experiments in live SET-2, HepG2, HuH7, and HEK293T cell lines and in mouse liver tissue. Unlike the HDAC protein abundance and biochemical activity against recombinant HDACs, the chemotype of the PRPs and the type of cells were key in defining the engagement of HDAC isoforms in live cells. Our findings suggest that engagement of HDAC isoforms by HDACi in vivo may be substantially modulated in a cell- and tissue-type-dependent manner.

Design and synthesis of novel photoaffinity reagents for labeling VEGF receptor tyrosine kinases

Novel biotin-tagged photoaffinity probes based on a trifunctional tertiary amine scaffold were synthesized and evaluated as vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors. Probes 3a-c inhibit VEGF induced proliferation in HUVE cells, w