1765-40-8 Usage
Description
Pentafluorobenzyl bromide (PFB-Br) is a versatile and effective alkylating reagent characterized by its clear colorless to yellowish liquid appearance. It is widely utilized in various chemical processes due to its ability to modify hydroxyl groups, carboxyl groups, sulfhydryl groups, and amines. PFB-Br is also known for its use in measuring nitrite and peroxynitrite levels, making it a valuable tool in analytical chemistry. Additionally, it serves as a lachrymator, which contributes to its effectiveness as a reagent.
Uses
Used in Analytical Chemistry:
Pentafluorobenzyl bromide is used as a derivatization reagent for enhancing the detection of certain compounds through electron capture detector (ECD) methods. Its alkylating properties allow for the modification of various functional groups, making it a suitable choice for a range of applications in this field.
Used in Gas Chromatography (GC):
PFB-Br is employed as a reagent for the derivatization of alcohols, carboxylic acids, and sulfonamides, which facilitates their analysis through gas chromatography. The formation of pentafluorobenzyl esters of organic acids using PFB-Br allows for more accurate determination by capillary and GC techniques.
Used in the Preparation of Pentafluorobenzyl Esters:
Pentafluorobenzyl bromide is used in the preparation of pentafluorobenzyl esters of organic acids, which are then determined by gas chromatography. This process aids in the identification and quantification of these acids in various samples.
Used in the Derivatization of N-7-Substituted Guanine Adducts of DNA:
PFB-Br is utilized to derivatize N-7-substituted guanine adducts of DNA for determination by GC-electron capture-MS. This application is particularly relevant in the study of DNA damage and repair mechanisms, as well as in the analysis of genetic mutations.
Used in the Measurement of Nitrite and Peroxynitrite:
Pentafluorobenzyl bromide is also used to measure nitrite and peroxynitrite levels, which are important parameters in various chemical and biological processes. Its ability to act as an alkylating agent makes it a valuable tool in this context.
Check Digit Verification of cas no
The CAS Registry Mumber 1765-40-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,6 and 5 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1765-40:
(6*1)+(5*7)+(4*6)+(3*5)+(2*4)+(1*0)=88
88 % 10 = 8
So 1765-40-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H2BrF5/c8-1-2-3(9)5(11)7(13)6(12)4(2)10/h1H2
1765-40-8Relevant articles and documents
Analysis of hydrogen bonding strengths in proteins using unnatural amino acids
Thorson, Jon S.,Chapman, Eli,Schultz, Peter G.
, p. 9361 - 9362 (1995)
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Visible-light-promoted Wohl-Ziegler functionalization of organic molecules with N-bromosuccinimide under solvent-free reaction conditions
Jereb, Marjan,Zupan, Marko,Stavber, Stojan
experimental part, p. 555 - 566 (2009/09/06)
The visible-light-induced transformation of toluenes with N-bromosuccinimide (NBS) under solvent-free reaction conditions (SFRC) was studied. The reaction took place in spite of the very restricted molecular motion; toluenes could be regioselectively converted to benzyl bromides. Selective radical-chain reactions with NBS were carried out in liquid/liquid and in solid/solid systems; furthermore, reactions could be performed in the presence of air. The radical scavenger TEMPO (=2,2,6,6-tetramethylpiperidin-1- yloxy) completely suppressed the side-chain bromination of toluenes with NBS under SFRC. Electron-withdrawing groups decreased the reactivity of the toluenes, and the Hammett reaction constant ρ+ = -1.7 indicated involvement of polar radical intermediates with electrophilic character.
Diphenyl ether derivatives
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, (2008/06/13)
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