887903-01-7

Basic information

• Product Name: 4-fluoro-2-trimethylsilanylethynylphenylamine
• Synonyms: 4-fluoro-2-trimethylsilanylethynylphenylamine
• CAS NO: 887903-01-7
• Molecular Weight: 207.323
• Mol File: 887903-01-7.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 4-fluoro-2-trimethylsilanylethynylphenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluoro-2-trimethylsilanylethynylphenylamine(887903-01-7)
• EPA Substance Registry System: 4-fluoro-2-trimethylsilanylethynylphenylamine(887903-01-7)

Safety Data

• Hazardous Substances Data: 887903-01-7(Hazardous Substances Data)

Upstream product

• 452-71-1 4-fluor-2-methylaniline 
• 1066-54-2 trimethylsilylacetylene 
• 1003-98-1 2-bromo-4-fluoroaniline 
• 61272-76-2 4-fluoro-2-iodoaniline 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 876-90-4 6-fluoro-1H-cinnolin-4-one 
• 2251-62-9 6-Fluor-4-chlor-cinnolin 
• 22614-75-1 6-fluoro-1H-quinolin-2-one 
• 791626-57-8 6-fluoroquinolin-2-amine 
• 604797-61-7 5-fluoro-2,3-diphenyl-1H-indole 

Relevant articles and documents

Solvent-Dependent Cyclization of 2-Alkynylanilines and ClCF2COONa for the Divergent Assembly of N-(Quinolin-2-yl)amides and Quinolin-2(1 H)-ones

Herein, we present an expedient Cu-catalyzed [5 + 1] cyclization of 2-alkynylanilines and ClCF2COONa to divergent construction of N-(quinolin-2-yl)amides and quinolin-2(1H)-ones by regulating the reaction solvents. Notably, nitrile acts as a solvent and performs the Ritter reactions. ClCF2COONa is used as a C1 synthon in this transformation, which also represents the first example for utilization of ClCF2COONa as an efficient desiliconization reagent. The current protocol involves in situ generation of isocyanide, copper-activated alkyne, Ritter reaction and protonation.

Sequential Sonogashira/intramolecular aminopalladation/cross-coupling ofortho-ethynyl-anilines catalyzed by a single palladium source: rapid access to 2,3-diarylindoles

We have developed a practical and efficient one-pot protocol for the synthesis of 2,3-diarylindolesviaPd-catalyzed bis-arylative cyclization of variouso-ethynylanilines with aryl iodides. Mechanism studies showed that a Pd-catalyzed Sonogashira reaction took place firstly, giving an internal alkyne intermediate, which subsequently underwent intramolecular aminopalladation/cross-coupling to give access to 2,3-diarylindoles. The present methodology exhibits a broad substrate scope, producing various 2,3-diaryl indoles bearing two different aryl groups.

Photoinduced Radical Cascade Cyclization: A Metal-Free Approach to Access Difluoroalkylated Dioxodibenzothiazepines

A simple and mild photoredox catalytic approach to access difluoroalkylated dioxodibenzothiazepines in high regioselectivity via radical cascade cyclization has been described herein. In contrast to previous methods, this strategy does not involve the use