88939-59-7Relevant articles and documents
MODELS OF FOLATE COENZYMES-VIII AN APPROACH TO YOHIMBANE ALKALOIDS VIA CARBON-FRAGMENT TRANSFER FROM N5,N10-METHYLENETETRAHYDROFOLATE MODELS
Hiemstra, H. C.,Bieraeugel, H.,Wijnberg, M.,Pandit, U. K.
, p. 3981 - 3986 (2007/10/02)
2-Substituted 1-tosyl-3,4,4-trimethylimidazolidines, prepared by the addition of anions to 1-tosyl-3,4,4-trimethyl-2-imidazolinium iodide 1, react with tryptamine in the presence of acetic acid to give 1-substituted β-carboline derivatives.The salt 1 reacts with anions of 2-CHR) to tryptamine to give pentacyclic products corresponding to the yohimbane skeleton.The product from 5c yields, after reduction of both the amide and the dithiane function, the precursor of epi- and allo-yohimbanes.