88987-42-2Relevant articles and documents
Platinum(II) Complexes of Functionalized Malonato Ligands: Unequivocal Synthesis, Interaction with a Tetradeoxyribonucleotide and Deoxyribonucleic Acid
Laurent, Jean-Pierre,Morvan, Bernard
, p. 2141 - 2146 (1993)
The unequivocal syntheses of four cis-> complexes has been achieved, avoiding any interaction between the pendant carboxyl group and the platinum.The complexes have been characterized by elemental analysis, 13C NMR and FAB mass spectroscopy.Their interaction with a tetradeoxyribonucleotide d(T-G-G-T) (G = guanosine, T = ribosylthymine) and DNA (in vitro) has been investigated to show that they form adducts of the type 7,N7'>> as do the known therapeutically activeplatinum complexes.However, the presence of the free carbonyl function increases significantly the reactivity with respect to that of the non-functionalized malonato complexes >.
Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)
Hu, Jiantao,Hu, Biao,Wang, Mingliang,Xu, Fuming,Miao, Bukeyan,Yang, Chao-Yie,Wang, Mi,Liu, Zhaomin,Hayes, Daniel F.,Chinnaswamy, Krishnapriya,Delproposto, James,Stuckey, Jeanne,Wang, Shaomeng
, p. 1420 - 1442 (2019/01/30)
The estrogen receptor (ER) is a validated target for the treatment of estrogen receptor-positive (ER+) breast cancer. Here, we describe the design, synthesis, and extensive structure-activity relationship (SAR) studies of small-molecule ERα degraders base
Tri-Orthogonal Scaffolds for the Solid-Phase Synthesis of Peptides
Pícha, Jan,Fabre, Benjamin,Budě?ínsky, Milo?,Hajduch, Jan,Abdellaoui, Mehdi,Jirá?ek, Ji?í
supporting information, p. 5180 - 5192 (2018/08/01)
Multi-orthogonal scaffolds can be useful for the attachment of several different compounds to the same central skeleton. Such compounds can find applications in the development of protein mimics because of their potential to mimic several distant epitopes