89-38-3

Basic information

• Product Name: Pteroyltriglutamic
• Synonyms: Pteroyltriglutamic;2-[[4-[[4-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]-4-carboxy-butanoyl]amino]-4-carboxy-butanoyl]amino]pentanedioic acid;Pteroyltriglutamic acid;pteropterin;N-[N-[N-[4-[[(2-Amino-1,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]-L-γ-glutamyl]-L-γ-glutamyl]-L-glutamic acid;2-[[4-[[4-[[4-[(2-amino-4-keto-1H-pteridin-6-yl)methylamino]benzoyl]amino]-5-hydroxy-5-keto-pentanoyl]amino]-5-hydroxy-5-keto-pentanoyl]amino]glutaric acid;2-[[4-[[4-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]-5-hydroxy-5-oxopentanoyl]amino]-5-hydroxy-5-oxopentanoyl]amino]pentanedioic acid;2-[[4-[[4-[[4-[(2-azanyl-4-oxo-1H-pteridin-6-yl)methylamino]phenyl]carbonylamino]-5-hydroxy-5-oxo-pentanoyl]amino]-5-hydroxy-5-oxo-pentanoyl]amino]pentanedioic acid
• CAS NO: 89-38-3
• Molecular Formula: C₂₉H₃₃N₉O₁₂
• Molecular Weight: 669.648
• Mol File: 89-38-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.68±0.1 g/cm3(Predicted)
• Refractive Index: 1.691
• PKA: 3.39±0.10(Predicted)
• CAS DataBase Reference: Pteroyltriglutamic(CAS DataBase Reference)
• NIST Chemistry Reference: Pteroyltriglutamic(89-38-3)
• EPA Substance Registry System: Pteroyltriglutamic(89-38-3)

Safety Data

• Hazardous Substances Data: 89-38-3(Hazardous Substances Data)

Usage

Uses

Pteroyltri-γ-L-glutamic acid is a folate derivative found in various foods such as yeast, spinach, beef liver, beef fillet and peas.

InChI:InChI=1/C29H33N9O12/c30-29-37-23-22(25(44)38-29)33-15(12-32-23)11-31-14-3-1-13(2-4-14)24(43)36-18(28(49)50)6-9-20(40)34-16(26(45)46)5-8-19(39)35-17(27(47)48)7-10-21(41)42/h1-4,12,16-18,31H,5-11H2,(H,34,40)(H,35,39)(H,36,43)(H,41,42)(H,45,46)(H,47,48)(H,49,50)(H3,30,32,37,38,44)/t16-,17-,18-/m0/s1

Upstream product

• 121175-95-9 (S)-2-[(S)-4-((S)-4-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid 
• 45120-30-7 L-glutamic acid α-tert-butyl ester 
• 84793-07-7 Fmoc-Glu-OtBu 
• 124126-68-7 α-tert-butyl N-<(9-fluorenylmethoxy)oxy>carbonyl-L-glutamic anhydride 
• 63948-16-3 α-tert-butyl N¹⁰-(trifluoroacetyl)pteroyltriglutamate 

Relevant articles and documents

Folate analogues. 33. Synthesis of folate and antifolate poly-γ-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cel

Representative examples of folate and antifolate poly-γ-glutamyl metabolites were synthesized via the [(9-fluorenylmethoxy)oxy]carbonyl (Fmoc) chemistry using the KH polyamide resin. Polyglutamate yields were consistently better in all cases compared to t